Associating liver partition and portal vein ligation for staged hepatectomy: From technical evolution to oncological benefit

Table 1 Recent published studies on associating liver partition and portal vein ligation for staged hepatectomy (only case series with more than 10 patients are listed)

Ref.	Date (yr)	Total cases (center involved)	Interval1(d)	FLR hypertrophy (median)	Completion stage 2	R0 resection	PHLF	Morbidity2	In-hospital mortality	Follow-up (median, months)	Recurrence	Overall survival
Schnitzbauer et al[1]	2012	25 (5)	9	74%	88%	96%	-	Overall: 64% ≥ III: 40%	12%	6	20%	86% at 6 m
Torres et al[29]	2013	39 (9)	14	83%	94.80%	100%	-	Overall: 59%	12.80%	-	-	-
Schadde et al[10]	2014	202 (56)	7	80%	98%	91%	-	≥ III: 40%	9%	9	40% at 12 m	73% at 12 m
Truant et al[4]	2015	62 (9)	8	48.60%	95.20%	-	25.8%	≥ III: 40.3%	12.90%	-	-	-
Robles et al[11]	2014	22 (1)	7	61%	100%	100%	22.7%	Overall: 64%	9%	6	5%	91% at 6 m
Nadalin et al[53]	2014	15 (1)	10	87.20%	100%	87%	-	Overall: 67%	28.70%	17	29%	67% at 17 m
Alvarez et al[15]	2015	30 (1)	6	89.70%	93%	93%	14%	Overall: 53% ≥ III: 43%	6.60%	17	22% at 12 m	67% at 12 m
Petrowsky et al[16]	2015	24 (1)	7	61%	100%	-	-	≥ IIIb: 33%	16.70%	-	-	-
Hernandez- Alejandro et al[17]	2015	14 (1)	7	93%	100%	86%	29%	Overall: 36% ≥ IIIb: 14%	0%	9	14%	100% at 9 m
Tanaka et al[21]	2015	11 (1)	7	54%	100%	100% (R0/R1)	18%	Overall: 46% ≥ III: 27%	9%	-	-	-
Chan et al[50]	2015	17 (1)	6	48.70%	100%	-	-	≥ III: 11.8%	5.90%	-	-	-

¹Interval: Median days from the stage 1 to CT scan;

²Morbidity: Clavien-Dindo classification was applied; FLR: Future liver remnant; PHLF: Post-hepatectomy liver failure according to 50-50 criteria (35).