Li J, Ewald F, Gulati A, Nashan B. Associating liver partition and portal vein ligation for staged hepatectomy: From technical evolution to oncological benefit. World J Gastrointest Surg 2016; 8(2): 124-133 [PMID: 26981186 DOI: 10.4240/wjgs.v8.i2.124]
Corresponding Author of This Article
Jun Li, MD, Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. j.li@uke.de
Research Domain of This Article
Surgery
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Feb 27, 2016; 8(2): 124-133 Published online Feb 27, 2016. doi: 10.4240/wjgs.v8.i2.124
Associating liver partition and portal vein ligation for staged hepatectomy: From technical evolution to oncological benefit
Jun Li, Florian Ewald, Amit Gulati, Björn Nashan
Jun Li, Florian Ewald, Björn Nashan, Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Amit Gulati, Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Author contributions: Li J design of the study, literature review and analysis, drafted and wrote the final version of the manuscript; Ewald F literature review, drafted and wrote the final version of the manuscript; Gulati A literature review, drafted and wrote the final version of the manuscript; Nashan B design of the study, critical revision, edited and final approval of the final version
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jun Li, MD, Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. j.li@uke.de
Telephone: +49-40-741058572 Fax: +49-40-741045001
Received: August 7, 2015 Peer-review started: August 10, 2015 First decision: September 18, 2015 Revised: October 8, 2015 Accepted: December 9, 2015 Article in press: December 11, 2015 Published online: February 27, 2016 Processing time: 205 Days and 1.4 Hours
Abstract
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel approach in liver surgery that allows for extensive resection of liver parenchyma by inducing a rapid hypertrophy of the future remnant liver. However, recent reports indicate that not all patients eligible for ALPPS will benefit from this procedure. Therefore, careful patient selection will be necessary to fully exploit possible benefits of ALPPS. Here, we provide a comprehensive overview of the technical evolution of ALPPS with a special emphasis on safety and oncologic efficacy. Furthermore, we review the contemporary literature regarding indication and benefits, but also limitations of ALPPS.
Core tip: We provide a comprehensive overview of the technical evolution of Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) with a special emphasis on safety and oncologic efficacy. Furthermore, we review the contemporary literature regarding indication and benefits, but also limitations of ALPPS.
