Efficacy of linaclotide with polyethylene glycol at high risk of inadequate bowel preparation: A randomized controlled trial

Table 1 Comparison of general information between the two groups of population

Groups	3 L PEG group (n = 81)	3 L PEG + L group (n = 80)	P value
Age			0.183
< 70 years	16	23
≥ 70 years	65	57
Gender			0.820
Male	47	45
Female	34	35
BMI			0.238
< 25 kg/m2	55	61
≥ 25 kg/m2	26	19
Cigarette smoking	20	13	0.185
Alcohol drinking	15	12	0.550
Comorbidity
Diabetes mellitus	21	30	0.115
Hypertension	41	42	0.811
Coronary heart disease	17	16	0.877
Hyperlipemia	21	18	0.612
Indication for colonoscopy			0.061
Screening	27	16
Post-polypectomy surveillance	12	8
Diagnosis	42	56
History of abdominal surgery	19	21	0.682
History of constipation	9	16	0.120
History of colonoscopy	22	20	0.755

BMI: Body mass index; PEG: Polyethylene glycol; PEG + L: Polyethylene glycol plus linaclotide.

Table 2 Comparison of the Boston score between the two groups, mean ± SD

Segment	3 L PEG (n = 81)	Linaclotide + 3 L PEG (n = 80)	Difference between groups (95%CI)	P value
Right colon	1.642 ± 0.577	1.938 ± 0.512	0.296 (0.126-0.465)	< 0.001
Transverse colon	1.938 ± 0.659	2.350 ± 0.618	0.412 (0.213-0.611)	< 0.001
Left colon	2.012 ± 0.581	2.513 ± 0.595	0.500 (0.317-0.683)	< 0.001
Total BBPS	5.593 ± 1.579	6.800 ± 1.444	1.207 (0.736-1.679)	< 0.001
Adequate prep (%)	58.025	86.250	28.230 (15.100-42.840)	< 0.001

BBPS: Boston bowel preparation scale; CI: Confidence interval; PEG: Polyethylene glycol.

Table 3 Comparison of polyp detection rates and adenoma detection rates between the two groups, n (%)

Groups	3 L PEG (n = 81)	Linaclotide + 3 L PEG (n = 80)	Difference between groups (95%CI)	P value
PDR	50 (61.728)	53 (66.250)	4.522 (-10.690 to 20.040)	0.550
ADR	33 (40.741)	36 (45.000)	4.259 (-11.380 to 20.170)	0.585

PDR: Polyp detection rate; ADR: Adenoma detection rate; CI: Confidence interval; PEG: Polyethylene glycol.

Table 4 Comparison of polyp characters in patients with detected polyps between the two groups, mean ± SD

Groups	3 L PEG (n = 50)	Linaclotide + 3 L PEG (n = 53)	Difference between groups (95%CI)	P value
Number of polyps	2.580 ± 1.808	2.528 ± 1.772	-0.052 (-0.752 to 0.648)	0.829
Size of polyps	1.034 ± 0.920	1.066 ± 0.864	0.032 (-0.317 to 0.381)	0.723
Number of adenoma	1.620 ± 1.872	1.528 ± 1.612	-0.092 (-0.774 to 0.590)	0.988

CI: Confidence interval; PEG: Polyethylene glycol.

Table 5 Comparison of adverse events between the two groups

Rates of adverse events	3 L PEG (n = 81)	Linaclotide + 3 L PEG (n = 80)	P value
Nausea	16	13	0.563
Vomiting	6	4	0.760
Abdominal pain	7	5	0.781
Abdominal bloating	10	7	0.627
Dizziness	5	4	0.985
Headache	4	2	0.689

PEG: Polyethylene glycol.