Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Jun 27, 2026; 18(6): 119538
Published online Jun 27, 2026. doi: 10.4240/wjgs.119538
Published online Jun 27, 2026. doi: 10.4240/wjgs.119538
Efficacy of linaclotide with polyethylene glycol at high risk of inadequate bowel preparation: A randomized controlled trial
Wei-Min Li, Xiao-Peng Wang, Yi-Jie Sun, Guo-Dong Li, Jia-Qi Wu, Department of Gastro
Yu-Xuan Li, School of Clinical Medicine, Hangzhou Normal University, Hangzhou 310000, Zhejiang Province, China
Yi-Dong Wang, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Co-first authors: Wei-Min Li and Xiao-Peng Wang.
Author contributions: Li WM and Wang XP contributed equally to this work as co-first authors, and were primarily responsible for conceptualization, design, data collection, formal analysis and writing-original draft; Wu JQ contributed to conceptualization, design, data collection, formal analysis and writing-original draft; Li YX and Sun YJ contributed to data collection, formal analysis; Wang YD and Li GD contributed to design, formal analysis, writing-review and editing, supervision; and all authors read and approved the final manuscript.
Supported by the Hangzhou Biomedical and Health Industry Development Support Technology Special Project, No. 2023WJC080; and the Hangzhou Medical and Health Science and Technology Project, No. A20251519.
Institutional review board statement: The study was approved by the Institutional Review Board of the Affiliated Hospital of Hangzhou Normal University, No. 2023(E2)-HS-033.
Clinical trial registration statement: This trial was registered in the Chinese Clinical Trial Registry (No. ChiCTR2500111663).
Informed consent statement: All study participants were fully informed. Written informed consents were obtained from all participants.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The datasets used in this study are available from the corresponding author on reasonable request.
Corresponding author: Jia-Qi Wu, MD, Doctor, Department of Gastroenterology, The Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhou Road, Hangzhou 310000, Zhejiang Province, China. wujiaqi_12@126.com
Received: February 2, 2026
Revised: March 11, 2026
Accepted: April 1, 2026
Published online: June 27, 2026
Processing time: 141 Days and 23.6 Hours
Revised: March 11, 2026
Accepted: April 1, 2026
Published online: June 27, 2026
Processing time: 141 Days and 23.6 Hours
Core Tip
Core Tip: This randomized controlled trial evaluated the efficacy of 3 L polyethylene glycol combined with linaclotide in patients at high risk of inadequate bowel preparation. Linaclotide significantly improved bowel cleansing and the adequacy of bowel preparation. No differences were observed between the groups in adenoma detection rate, polyp detection rate, polyp characteristics, or adverse events. This novel evidence supports the use of 3 L polyethylene glycol with linaclotide for bowel cleansing in high-risk populations.