Vascular allocation between liver and pancreas allografts: A retrospective single-center study

Table 1 Patients characteristic of pancreas-using group and non-pancreas-using group, n (%)/median (interquartile range)/mean ± SD

	Non-PUG (n = 68)	PUG (n = 34)	P value
Age (year)	55.34 ± 15.27	51.91 ± 10.77	0.814
Gender (male)	55 (80.9)	25 (73.5)	0.395
Height (cm)	171.22 ± 7.29	170.18 ± 6.96	0.49
Weight (kg)	69.10 ± 13.24	69.18 ± 17.46	0.978
Creatinine (μmol/L)	75.32 ± 39.33	69.14 ± 18.09	0.386
Albumin (g/L)	34.99 ± 6	35.33 ± 5.41	0.78
Model for end-stage liver disease score	15.94 ± 8.55	15.00 ± 6.70	0.576
Total bilirubin (μmol/L)	39.73 (18.20-83.43)	38.40 (16.26-73.3)	0.696
Alpha-fetoprotein (μg/L)	4.54 (2.13-13.48)	7.6 (2.32 ± 90.61)	0.255
Child-Pugh score
A	29 (42.6)	10 (29.4)	0.42
B	19 (27.9)	12 (35.3)
C	20 (29.4)	12 (35.3)
Primary disease			0.936
Benign end-stage disease	32 (47.1)	17 (50)
Liver malignant disease	27 (39.7)	14 (41.2)
Congenital, metabolic disease	2 (2.9)	1 (2.9)
Acute or subacute liver failure	7 (10.3)	2 (5.9)

PUG: Pancreas-using group.

Table 2 Intraoperative characteristic of pancreas-using group and non-pancreas-using group, n (%)/median (interquartile range)/mean ± SD

	Non-PUG (n = 68)	PUG (n = 34)	P value
Donor age (year)	36.65 ± 8.01	35.4 ± 8.86	0.501
Donor gender (male)	59 (86.8)	30 (88.2)	0.834
Donor height (cm)	168.68 ± 7.17	168.97 ± 6.58	0.848
Donor weight (kg)	70 (58-79)	65 (60-70)	0.329
Cold ischemic time (hours)	3.32 ± 3.14	2.21 ± 2.05	0.101
Blood loss (mL)	1550 (1000-2350)	1500 (850-2000)	0.261
Red blood cell infusion (u)	10 (6-12.5)	10 (6-12)	0.691
Plasma infusion (mL)	1700 (1000-2000)	1200 (1000-2000)	0.371
Operation time (hours)	7.26 ± 1.97	7.07 ± 2.25	0.665

PUG: Pancreas-using group.

Table 3 Postoperative characteristic and complications of pancreas-using group and non-pancreas-using group, n (%)/median (interquartile range)

	Non-PUG (n = 68)	PUG (n = 34)	P value
Intensive care unit stay (hours)	65.5 (45.75-86)	61 (46-70)	0.709
Hospitalization (day)	29 (21-56.5)	28 (23-52)	0.965
Abdominal hemorrhage	4 (5.9)	1 (2.9)	0.517
Hepatic artery thrombosis	1 (1.5)	0	1
Hepatic artery stenosis	3 (4.4)	0	0.549
Splenic artery stealing syndrome	1 (1.5)	0	1
PV stenosis	2 (2.9)	0	0.551
PV thrombosis	0	0	Not available
Bile leakage	10 (14.7)	1 (2.9)	0.095
Biliary strictures	4 (5.9)	3 (8.8)	0.683

PV: Portal vein; PUG: Pancreas-using group.

Table 4 The 24 hours, 48 hours, 72 hours rate of descent of alanine aminotransferase, aspartate aminotransferase, total bilirubin in pancreas-using group and non-pancreas-using group, mean ± SD

	Non-PUG (n = 68)	PUG (n = 34)	P value
24 hours rate of descent (AST)	0.6 ± 0.47	0.69 ± 0.17	0.163
48 hours rate of descent (AST)	0.8 ± 0.21	0.84 ± 0.11	0.21
72 hours rate of descent (AST)	0.83 ± 0.4	0.87 ± 0.14	0.462
24 hours rate of descent (ALT)	0.27 ± 0.29	0.31 ± 0.18	0.395
48 hours rate of descent (ALT)	0.45 ± 0.26	0.5 ± 0.16	0.235
72 hours rate of descent (ALT)	0.57 ± 0.29	0.61 ± 0.19	0.406
24 hours rate of descent (TBIL)	0.32 ± 0.39	0.38 ± 0.34	0.447
48 hours rate of descent (TBIL)	0.3 ± 0.49	0.35 ± 0.42	0.612
72 hours rate of descent (TBIL)	0.27 ± 0.44	0.33 ± 0.39	0.502

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PUG: Pancreas-using group; TBIL: Total bilirubin.

Table 5 Alanine aminotransferase, aspartate aminotransferase, total bilirubin decreased to normal within 7 days in pancreas-using group and non-pancreas-using group, n (%)

	Non-PUG (n = 68)	PUG (n = 34)	P value
Alanine aminotransferase decreased to normal within 7 days	23 (33.8)	14 (41.2)	0.467
Aspartate aminotransferase decreased to normal within 7 days	55 (80.9)	32 (94.1)	0.075
Total bilirubin decreased to normal within 7 days	33 (48.5)	25 (73.5)	0.016a

^aP < 0.05 indicates statistical significance.

PUG: Pancreas-using group.

Table 6 Surgical complications of simultaneous pancreas-kidney in 34 recipients, n (%)

Surgical complications	Intestinal fistula	Transplanted renal artery thrombosis	Transplanted pancreatic thrombosis	Intestinal bleeding
	1 (2.94)	1 (2.94)	1 (2.94)	4 (11.76)

One patient with intestinal fistula improved after conservative management with continuous negative pressure irrigation. One patient with thrombosis of the renal transplant artery underwent graft resection, and one patient with thrombosis of the pancreatic graft underwent graft resection. Among four patients with intestinal bleeding, they were all improved with conservative and symptomatic management.