Targeting obesity and lipid metabolism profiles to prevent perianal abscesses: A case-control study and Mendelian randomization analysis

Table 1 Baseline characteristics of all participants, n (%)

Variable	Status	Total (n = 1071)	Normal (n = 595)	Case (n = 476)	P value	W value
Age (years) [median (IQR)]		36.0 (31.0-44.0)	38.0 (32.0-47.0)	35.0 (30.0-42.0)	< 0.001	166281.5
Sex	Female	398 (37.2)	321 (53.9)	77 (16.2)	< 0.001
	Male	673 (62.8)	274 (46.1)	399 (83.8)
Body mass index (kg/m2) [median (IQR)]		24.2 (21.8-27.2)	23.1 (20.8-25.6)	26.1 (23.3-29.4)	< 0.001	83028.5
waist-to-hip ratio [median (IQR)]		0.8 (0.8-0.9)	0.8 (0.8-0.8)	0.9 (0.9-1.0)	< 0.001	40010.5
waist-to-height ratio [median (IQR)]		0.5 (0.4-0.5)	0.4 (0.4-0.5)	0.5 (0.5-0.6)	< 0.001	50096
glucose (mmol/L) [median (IQR)]		5.0 (4.7-5.5)	5.0 (4.6-5.3)	5.2 (4.8-5.6)	< 0.001	109062.5
glycated albumin (%) [median (IQR)]		13.2 (12.4-14.2)	13.4 (12.6-14.3)	13.0 (12.1-14.0)	< 0.001	167984
Urea (mmol/L) [median (IQR)]		4.5 (3.9-5.4)	4.5 (3.8-5.4)	4.6 (3.9-5.5)	0.048	131657.5
Uric acid (μmol/L) [median (IQR)]		358.0 (290.0-420.0)	323.0 (268.0-384.0)	403.0 (343.0-473.5)	< 0.001	78655
Cholesterol (mmol/L) [median (IQR)]		4.6 (4.0-5.1)	4.4 (3.8-4.9)	4.8 (4.3-5.4)	< 0.001	96592.5
Triglycerides (mmol/L) [median (IQR)]		1.1 (0.8-1.6)	0.9 (0.7-1.4)	1.4 (1.0-2.1)	< 0.001	84128.5
High-density lipoprotein cholesterol (mmol/L) [median (IQR)]		1.2 (1.0-1.5)	1.3 (1.1-1.5)	1.1 (1.0-1.3)	< 0.001	199218.5
Low-density lipoprotein cholesterol (mmol/L) [median (IQR)]		2.5 (2.1-2.9)	2.3 (2.0-2.7)	2.7 (2.3-3.2)	< 0.001	94032.5

W: Mann-Whitney test’s W statistics. P < 0.05 was considered statistically significant. IQR: Interquartile range.