Microsatellite instability and its impact on nutritional and inflammatory profiles in colorectal cancer

Table 1 Summary of microsatellite instability-related nutritional and inflammatory features in colorectal cancer

Aspect	Findings	Ref.
Inflammatory profiles	MSI-H tumors are associated with higher neutrophil-to-lymphocyte ratio and pro-inflammatory cytokines	Yeo et al[1], 2023; Kibriya et al[2], 2024
Nutritional profiles	MSI-H patients often have lower high-density lipoprotein cholesterol and higher aspartate aminotransferase levels	Yeo et al[1], 2023; Yi et al[3], 2023
Nutritional interventions	Symbiotic supplementation reduces C-reactive protein levels in colorectal cancer patients	de Oliveira and Aarestrup[4], 2012
Tumor microenvironment	MSI-H tumors have robust lymphocytic infiltration and higher programmed death-1/programmed death ligand-1	Greco et al[5], 2023; Huang et al[6], 2020
Gut microbiome	MSI-H tumors are associated with distinct gut microbiota profiles	Sillo et al[7], 2023; Byrd et al[8], 2023

MSI-H: Microsatellite instability-high.