Qu HD, Gao X, Xiao P, Jiao Y. Microsatellite instability and its impact on nutritional and inflammatory profiles in colorectal cancer. World J Gastrointest Surg 2025; 17(9): 108215 [DOI: 10.4240/wjgs.v17.i9.108215]
Corresponding Author of This Article
Yan Jiao, PhD, Surgeon, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. lagelangri1@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Sep 27, 2025; 17(9): 108215 Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.108215
Microsatellite instability and its impact on nutritional and inflammatory profiles in colorectal cancer
Hong-Da Qu, Xue Gao, Ping Xiao, Yan Jiao
Hong-Da Qu, Department of Central Sterile Supply, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Xue Gao, Ping Xiao, Department of The First Operation Room, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Qu HD and Gao X contributed to the discussion, design of the manuscript and literature search; Xiao P designed the overall concept and outline of the manuscript; Jiao Y contributed to the writing, editing of the manuscript, and literature search; all authors have read and approve the final manuscript.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Jiao, PhD, Surgeon, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. lagelangri1@126.com
Received: April 8, 2025 Revised: April 12, 2025 Accepted: April 24, 2025 Published online: September 27, 2025 Processing time: 169 Days and 20 Hours
Core Tip
Core Tip: Microsatellite instability-high (MSI-H) colorectal cancer (CRC) represents a biologically distinct subtype characterized not only by its genetic and immunological features but also by unique systemic alterations. Patients with MSI-H CRC often present with heightened systemic inflammation, as evidenced by elevated neutrophil-to-lymphocyte ratio, and impaired nutritional status, including lower body mass index, serum albumin, and altered lipid metabolism. These immunonutritional profiles have direct implications for prognosis, treatment tolerance, and response to immunotherapy. Recognizing the impact of MSI on host systemic status supports a more integrated, personalized approach to patient care, emphasizing the value of nutritional support, anti-inflammatory strategies, and microbiome modulation as potential adjuncts to immunotherapy and conventional treatment.
