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Meta-Analysis
Copyright ©The Author(s) 2025.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 106654
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.106654
Table 1 General information of included studies
Ref.
Research type
Sample size
Age (mean ± SD, year)
Male/female
Surgical methods
Research period
Observation
Control
Observation
Control
Observation
Control
Observation
Control
Chen[19], 2021RCT353563.57 ± 2.1863.51 ± 2.1218/1719/1611 cases of proximal gastrectomy, 9 cases of total gastrectomy, and 15 cases of distal gastrectomy12 cases of proximal gastrectomy, 8 cases of total gastrectomy, and 15 cases of distal gastrectomyJanuary 2020 to January 2021
Bi et al[20], 2024RCT333356.04 ± 7.1155.73 ± 7.0912/2118/1512 cases of distal gastrectomy + gastrojejunostomy, and 21 cases of proximal gastrectomy + esophagogastrostomy14 cases of distal gastrectomy + gastrojejunostomy, and 19 cases of proximal gastrectomy + esophagogastrostomyOctober 2020 to June 2021
Zhao and Sun[21], 2024RCT585760.37 ± 5.760.09 ± 5.8137/2135/2223 cases of proximal gastrectomy, and 34 cases of distal gastrectomy26 cases of proximal gastrectomy, and 32 cases of distal gastrectomyJune 2020 to August 2022
Wu et al[22], 2021RCT494956.43 ± 10.0160.09 ± 5.8128/2127/2235 cases of open surgery, and 14 cases of laparoscopic surgery38 cases of open surgery, and 11 cases of laparoscopic surgeryApril 2018 to November 2019
Li and Zhu[23], 2023RCT293061.9 ± 11.862.6 ± 12.812/1712/1829 cases of radical gastrectomy30 cases of radical gastrectomySeptember 2020 to September 2022
Yuan et al[24], 2021RCT414155.65 ± 7.4955.69 ± 7.4225/1627/1441 cases of radical gastrectomy41 cases of radical gastrectomyJune 2017 to June 2019
Kang et al[25], 2021RCT545418-7518-75////June 2019 to January 2021
Liu and Xu[26], 2022RCT484863.86 ± 7.7363.18 ± 7.6828/2031/1729 cases of distal gastrectomy + gastrojejunostomy, and 19 cases of proximal gastrectomy + esophagogastrostomy31 cases of distal gastrectomy + gastrojejunostomy, and 17 cases of proximal gastrectomy + esophagogastrostomyJanuary 2019 to July 2021