Methyltransferase-like factor 14 pathway and its relationship with pathological stages in patients undergoing surgery for colorectal cancer

Table 1 Comparison of positive methyltransferase-like factor 14 expression between the two groups, n (%)

Group	Number of cases	Positive expression	Negative expression
Tumor tissue	80	31 (38.75)	49 (61.25)
Tissue adjacent to the carcinoma tissue	80	64 (80.00)	16 (20.00)
χ2		28.217
P value		< 0.001

Table 2 Comparison of methyltransferase-like factor 14 expression among patients with different clinicopathologies, n (%)

Clinical pathology data	Positive expression (n = 31)	Negative expression (n = 49)	χ2	P value
Gender			0.024	0.877
Male (n = 43)	17 (39.53)	26 (60.47)
Female (n = 37)	14 (37.84)	23 (62.16)
Age (years)			0.079	0.779
≤ 60 (n = 48)	18 (37.50)	30 (62.50)
> 60 (n = 32)	13 (40.63)	19 (59.37)
Tissue typing			0.427	0.808
Poorly differentiated (n = 30)	13 (43.33)	17 (56.67)
Moderately differentiated (n = 28)	10 (35.71)	18 (64.29)
Well differentiated (n = 22)	8 (36.36)	14 (63.67)
Tumor location			0.026	0.872
Rectal carcinoma (n = 52)	20 (38.46)	32 (60.54)
Carcinoma of colon (n = 28)	11 (39.29)	17 (60.71)
Tumor diameter (cm)			0.007	0.935
≤ 4 (n = 34)	13 (38.24)	21 (61.76)
> 4 (n = 46)	18 (39.13)	28 (60.87)
Lymphatic metastasis			8.988	0.003
Yes (n = 23)	3 (13.04)	20 (86.96)
No (n = 57)	28 (49.12)	29 (50.88)
Infiltration depth			12.603	0.001
T1 + T2 (n = 42)	24 (57.14)	18 (42.86)
T3 + T4 (n = 38)	7 (18.42)	31 (81.58)
TNM stage			15.393	0.001
I (n = 21)	18 (85.71)	3 (14.29)
II (n = 30)	10 (33.33)	20 (66.67)
III (n = 29)	3 (10.34)	26 (89.64)

TNM: Tumor, node, and metastasis.

Table 3 Comparison of methyltransferase-like factor 14 mRNA expression among patients with different clinicopathologies (mean ± SD)

Clinical pathology data	METTL14 mRNA expression	t	P value
Sex		1.724	0.089
Male (n = 43)	0.13 ± 0.03
Female (n = 37)	0.14 ± 0.02
Age (years)		1.205	0.232
≤ 60 (n = 48)	0.12 ± 0.04
> 60 (n = 32)	0.13 ± 0.03
Tissue typing		1.294	0.280
Poorly differentiated (n = 30)	0.13 ± 0.03
Moderately differentiated (n = 28)	0.12 ± 0.02
Well differentiated (n = 22)	0.12 ± 0.03
Tumor location		1.240	0.219
Rectal carcinoma (n = 52)	0.14 ± 0.04
Carcinoma of colon (n = 28)	0.13 ± 0.02
Tumor diameter (cm)		1.866	0.066
≤ 4 (n = 34)	0.13 ± 0.01
> 4 (n = 46)	0.14 ± 0.03
Lymphatic metastasis		5.878	< 0.001
Yes (n = 23)	0.10 ± 0.02
No (n = 57)	0.14 ± 0.03
Infiltration depth		8.780	< 0.001
T1 + T2 (n = 42)	0.16 ± 0.04
T3 + T4 (n = 38)	0.09 ± 0.03
TNM stage		43.442	< 0.001
I (n = 21)	0.16 ± 0.04
II (n = 30)	0.11 ± 0.03
III (n = 29)	0.08 ± 0.02

TNM: Tumor, node, and metastasis; METTL14: Methyltransferase-like factor 14.