Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. May 27, 2025; 17(5): 101674
Published online May 27, 2025. doi: 10.4240/wjgs.v17.i5.101674
Methyltransferase-like factor 14 pathway and its relationship with pathological stages in patients undergoing surgery for colorectal cancer
Qun Dai, Peng-Fei Ma, Jing Tian, Zhan Zhang, Qin Fang, Zi-Yu Lin, Li-Li Wu, Xue-Min Li
Qun Dai, Jing Tian, Qin Fang, Zi-Yu Lin, Li-Li Wu, Xue-Min Li, Department of Pathology, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, Hefei 230022, Anhui Province, China
Peng-Fei Ma, Department of Gastroenterology, Children’s Hospital of Fudan University at Anhui, Anhui Provincial Children’s Hospital, Hefei 230022, Anhui Province, China
Zhan Zhang, Department of Pathology, South District, The First Affiliated Hospital of Anhui Medical University, Feixi 231200, Anhui Province, China
Author contributions: Dai Q designed the study; Ma PF and Tian J analyzed the data; Dai Q, Ma PF, Tian J, Zhang Z, Fang Q, Lin ZY, Wu LL, and Li XM were involved in the data collection and wrote the manuscript; All authors critically reviewed and provided final approval of the manuscript, and all authors were responsible for the decision to submit the manuscript for publication.
Institutional review board statement: This investigation was reviewed and approved by the Institutional Review Board of the Third People's Hospital of Hefei, No. 2021-019.
Informed consent statement: All study participants or their legal guardians provided written informed consent before enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Tian, MD, Chief Physician, Department of Pathology, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, No. 204 Wangjiang East Road, Hefei 230022, Anhui Province, China. 305820252@qq.com
Received: January 10, 2025
Revised: February 3, 2025
Accepted: March 18, 2025
Published online: May 27, 2025
Processing time: 132 Days and 17.9 Hours
Core Tip

Core Tip: This study underscores the critical role of methyltransferase-like factor 14 (METTL14) expression in colorectal cancer, demonstrating that low METTL14 levels are associated with advanced tumor features, including lymph node metastasis and higher tumor-node-metastasis stages. Our findings suggest that METTL14 could serve as a potential biomarker for predicting malignant behavior and survival outcomes in patients undergoing radical resection, offering new insights for clinical management and prognosis.