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©The Author(s) 2025.
World J Gastrointest Surg. Apr 27, 2025; 17(4): 104459
Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.104459
Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.104459
Table 1 General data, mean ± SD
General data | Modeling group (n = 98) | Validation group (n = 42) | χ2/t | P value |
Gender | 0.136 | 0.712 | ||
Male | 48 | 22 | ||
Female | 50 | 20 | ||
Age (years) | 56.12 ± 6.33 | 56.23 ± 6.27 | 0.094 | 0.925 |
ASA classification | 1.979 | 0.159 | ||
Class I-II | 41 | 23 | ||
Class III | 57 | 19 | ||
TNM staging | 0.510 | 0.775 | ||
Stage I | 38 | 19 | ||
Stage II | 29 | 11 | ||
Stage III | 31 | 12 |
Table 2 Baseline data, mean ± SD
Baseline data | Observation group (n = 54) | Control group (n = 44) | χ2/t | P value |
Gender | 0.347 | 0.556 | ||
Male | 25 | 23 | ||
Female | 29 | 21 | ||
Age (years) | 56.08 ± 6.23 | 56.04 ± 6.17 | 0.032 | 0.975 |
ASA classification | 0.059 | 0.807 | ||
Class I-II | 22 | 19 | ||
Class III | 32 | 25 | ||
TNM staging | 0.298 | 0.862 | ||
Stage I | 21 | 17 | ||
Stage II | 17 | 12 | ||
Stage III | 16 | 15 |
Table 3 Univariate analysis of postoperative cognitive dysfunction in colorectal cancer patients, mean ± SD
General data | Cognitive dysfunction group (n = 37) | Non-cognitive dysfunction group (n = 61) | χ2/t | P value |
Gender | 0.219 | 0.640 | ||
Male | 17 | 31 | ||
Female | 20 | 30 | ||
Age (years) | 56.44 ± 6.12 | 55.83 ± 7.12 | 0.433 | 0.666 |
BMI | 1.255 | 0.263 | ||
≥ 24 kg/m2 | 11 | 25 | ||
< 24 kg/m2 | 26 | 36 | ||
ASA classification | 1.097 | 0.295 | ||
Class I-II | 13 | 28 | ||
Class III | 24 | 33 | ||
Hypertension | 0.188 | 0.665 | ||
Presence | 10 | 19 | ||
Absence | 27 | 42 | ||
Diabetes | 4.353 | 0.037 | ||
Presence | 25 | 28 | ||
Absence | 12 | 33 | ||
Alcohol consumption | 4.183 | 0.041 | ||
Presence | 26 | 30 | ||
Absence | 11 | 31 | ||
TNM staging | 2.834 | 0.242 | ||
Stage I | 17 | 21 | ||
Stage II | 12 | 17 | ||
Stage III | 8 | 23 | ||
Smoking history | 0.414 | 0.520 | ||
Presence | 11 | 22 | ||
Absence | 26 | 39 | ||
Education (years) | 4.389 | 0.036 | ||
≥ 10 years | 22 | 23 | ||
< 10 years | 15 | 38 | ||
Marital status | 0.794 | 0.373 | ||
Married | 13 | 27 | ||
Unmarried/widowed | 24 | 34 | ||
Anesthesia duration | 5.143 | 0.023 | ||
≥ 4 hours | 25 | 22 | ||
< 4 hours | 12 | 29 | ||
Intraoperative blood loss | 4.832 | 0.028 | ||
≥ 300 mL | 26 | 29 | ||
< 300 mL | 11 | 32 | ||
Intraoperative hypoxemia | 8.543 | 0.003 | ||
Presence | 27 | 26 | ||
Absence | 10 | 35 | ||
Use of DEX during surgery | 9.770 | 0.002 | ||
Absence | 26 | 23 | ||
Presence | 11 | 38 | ||
Use of vasoactive agents during surgery | 4.353 | 0.037 | ||
Presence | 25 | 28 | ||
Absence | 12 | 33 | ||
Surgical duration | 7.368 | 0.007 | ||
≥ 90 minutes | 29 | 31 | ||
< 90 minutes | 8 | 30 | ||
Tumor location | 0.149 | 0.928 | ||
Proximal colon | 13 | 22 | ||
Distal colon | 11 | 16 | ||
Rectum | 13 | 23 | ||
SIRS scores | 5.939 | 0.015 | ||
≥ 3 points | 28 | 31 | ||
< 3 points | 9 | 30 | ||
Postoperative fasting duration | 0.103 | 0.748 | ||
≥ 3 days | 20 | 35 | ||
< 3 days | 17 | 26 |
Table 4 Assignment method
Factors | Assignment |
Diabetes | 1: Presence; 0: Absence |
Alcohol consumption | 1: Presence; 0: Absence |
Years of education | 1: ≥ 10 years; 0: < 10 years |
Anesthesia duration | 1: ≥ 4 hours; 0: < 4 hours |
Intraoperative blood loss | 1: ≥ 300 mL; 0: < 300 mL |
Intraoperative hypoxemia | 1: Presence; 0: Absence |
Intraoperative use of DEX | 1: Absence; 0: Presence |
Surgical time | 1: ≥ 90 minutes; 0: < 90 minutes |
Intraoperative use of vasoactive drugs | 1: Absence; 0: Presence |
SIRS score | 1: ≥ 3 points; 0: < 3 points |
Table 5 Risk factors of postoperative cognitive dysfunction in colorectal cancer patients
Factors | β value | SE value | χ2 value | OR | 95%CI | P value |
Diabetes | 1.613 | 0.713 | 5.118 | 5.018 | 1.241-20.297 | 0.024 |
Alcohol consumption | 1.589 | 0.623 | 6.505 | 4.899 | 1.445-16.611 | 0.011 |
Years of education | 1.317 | 0.723 | 3.318 | 3.732 | 0.905-15.396 | 0.069 |
Anesthesia duration | 1.369 | 0.933 | 2.153 | 3.931 | 0.631-24.476 | 0.143 |
Intraoperative blood loss | 1.283 | 0.689 | 3.467 | 3.607 | 0.935-13.922 | 0.063 |
Intraoperative hypoxemia | 1.592 | 0.634 | 6.305 | 4.914 | 1.418-17.024 | 0.012 |
Non-use of DEX during surgery | 1.337 | 0.629 | 4.518 | 3.808 | 1.110-13.064 | 0.034 |
Intraoperative use of vasoactive drugs | 1.371 | 0.735 | 3.479 | 3.939 | 0.933-16.637 | 0.063 |
Surgical time | 1.592 | 0.633 | 6.325 | 4.914 | 1.421-16.991 | 0.012 |
SIRS scores | 1.432 | 0.588 | 5.931 | 4.187 | 1.322-13.256 | 0.015 |
Table 6 Model validation
Model | Actual cognitive dysfunction | |||
Positive | Negative | Total | ||
Prediction of cognitive dysfunction | Positive | 21 | 4 | 25 |
Negative | 5 | 12 | 17 | |
Total | 26 | 16 | 42 |
- Citation: Zheng ZP, Zhang YG, Long MB, Ji KQ, Peng JY, He K. Construction of a risk prediction model for postoperative cognitive dysfunction in colorectal cancer patients. World J Gastrointest Surg 2025; 17(4): 104459
- URL: https://www.wjgnet.com/1948-9366/full/v17/i4/104459.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v17.i4.104459