Retrospective Study
Copyright ©The Author(s) 2025.
World J Gastrointest Surg. Apr 27, 2025; 17(4): 104459
Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.104459
Table 1 General data, mean ± SD
General data
Modeling group (n = 98)
Validation group (n = 42)
χ2/t
P value
Gender0.1360.712
Male4822
Female5020
Age (years)56.12 ± 6.3356.23 ± 6.270.0940.925
ASA classification1.9790.159
Class I-II4123
Class III5719
TNM staging0.5100.775
Stage I3819
Stage II2911
Stage III3112
Table 2 Baseline data, mean ± SD
Baseline data
Observation group (n = 54)
Control group (n = 44)
χ2/t
P value
Gender0.3470.556
Male2523
Female2921
Age (years)56.08 ± 6.2356.04 ± 6.170.0320.975
ASA classification0.0590.807
Class I-II2219
Class III3225
TNM staging0.2980.862
Stage I2117
Stage II1712
Stage III1615
Table 3 Univariate analysis of postoperative cognitive dysfunction in colorectal cancer patients, mean ± SD
General data
Cognitive dysfunction group (n = 37)
Non-cognitive dysfunction group (n = 61)
χ2/t
P value
Gender0.2190.640
Male1731
Female2030
Age (years)56.44 ± 6.1255.83 ± 7.120.4330.666
BMI1.2550.263
≥ 24 kg/m21125
< 24 kg/m22636
ASA classification1.0970.295
Class I-II1328
Class III2433
Hypertension0.1880.665
Presence1019
Absence2742
Diabetes4.3530.037
Presence2528
Absence1233
Alcohol consumption4.1830.041
Presence2630
Absence1131
TNM staging2.8340.242
Stage I1721
Stage II1217
Stage III823
Smoking history0.4140.520
Presence1122
Absence2639
Education (years)4.3890.036
≥ 10 years2223
< 10 years1538
Marital status0.7940.373
Married1327
Unmarried/widowed2434
Anesthesia duration5.1430.023
≥ 4 hours2522
< 4 hours1229
Intraoperative blood loss4.8320.028
≥ 300 mL2629
< 300 mL1132
Intraoperative hypoxemia8.5430.003
Presence2726
Absence1035
Use of DEX during surgery9.7700.002
Absence2623
Presence1138
Use of vasoactive agents during surgery4.3530.037
Presence2528
Absence1233
Surgical duration7.3680.007
≥ 90 minutes2931
< 90 minutes830
Tumor location0.1490.928
Proximal colon1322
Distal colon1116
Rectum1323
SIRS scores5.9390.015
≥ 3 points2831
< 3 points930
Postoperative fasting duration0.1030.748
≥ 3 days2035
< 3 days1726
Table 4 Assignment method
Factors
Assignment
Diabetes1: Presence; 0: Absence
Alcohol consumption1: Presence; 0: Absence
Years of education1: ≥ 10 years; 0: < 10 years
Anesthesia duration1: ≥ 4 hours; 0: < 4 hours
Intraoperative blood loss1: ≥ 300 mL; 0: < 300 mL
Intraoperative hypoxemia1: Presence; 0: Absence
Intraoperative use of DEX1: Absence; 0: Presence
Surgical time1: ≥ 90 minutes; 0: < 90 minutes
Intraoperative use of vasoactive drugs1: Absence; 0: Presence
SIRS score1: ≥ 3 points; 0: < 3 points
Table 5 Risk factors of postoperative cognitive dysfunction in colorectal cancer patients
Factors
β value
SE value
χ2 value
OR
95%CI
P value
Diabetes1.6130.7135.1185.0181.241-20.2970.024
Alcohol consumption1.5890.6236.5054.8991.445-16.6110.011
Years of education1.3170.7233.3183.7320.905-15.3960.069
Anesthesia duration1.3690.9332.1533.9310.631-24.4760.143
Intraoperative blood loss1.2830.6893.4673.6070.935-13.9220.063
Intraoperative hypoxemia1.5920.6346.3054.9141.418-17.0240.012
Non-use of DEX during surgery1.3370.6294.5183.8081.110-13.0640.034
Intraoperative use of vasoactive drugs1.3710.7353.4793.9390.933-16.6370.063
Surgical time1.5920.6336.3254.9141.421-16.9910.012
SIRS scores1.4320.5885.9314.1871.322-13.2560.015
Table 6 Model validation
ModelActual cognitive dysfunction
Positive
Negative
Total
Prediction of cognitive dysfunctionPositive21425
Negative51217
Total261642