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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Apr 27, 2025; 17(4): 104459
Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.104459
Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.104459
Construction of a risk prediction model for postoperative cognitive dysfunction in colorectal cancer patients
Zhen-Ping Zheng, Yong-Guo Zhang, Ming-Bo Long, Kui-Quan Ji, Jin-Yan Peng, Kai He, Department of Anesthesiology, The People’s Hospital of Qian Nan, Duyun 558000, Guizhou Province, China
Author contributions: Zheng ZP and He K contributed to the conception and design of the study, data acquisition and analysis, and analyzed the data and wrote the manuscript; Zhang YG assisted with study design; Long MB assisted with data collection; Ji KQ performed data analysis; Peng JY and He K supervised and coordinated the project.
Supported by the Research Fund of Qiannan Medical College for Nationalities, No. Qnyz202222.
Institutional review board statement: This study was approved by the Ethics Committee of The People’s Hospital of Qian Nan (No. 2024-qnzy-25).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kai He, Chief Physician, Department of Anesthesiology, The People’s Hospital of Qian Nan, No. 9 Wenfeng Road, Duyun 558000, Guizhou Province, China.
Received: December 27, 2024
Revised: February 6, 2025
Accepted: February 24, 2025
Published online: April 27, 2025
Processing time: 91 Days and 23.3 Hours
Revised: February 6, 2025
Accepted: February 24, 2025
Published online: April 27, 2025
Processing time: 91 Days and 23.3 Hours
Core Tip
Core Tip: This study developed a risk prediction model for postoperative cognitive dysfunction (POCD) in colorectal cancer (CRC) patients, identifying key risk factors such as diabetes, alcohol consumption, intraoperative hypoxemia, non-use of dexmedetomidine (DEX), surgery duration ≥ 90 minutes, and a systemic inflammatory response syndrome score ≥ 3. The model demonstrated good predictive performance, with high sensitivity and specificity, and highlights the preventive value of DEX in reducing POCD incidence. This research provides valuable insights for improving POCD prevention and management in CRC patients.