Effects of Bifidobacterium triple viable bacteria-assisted mirtazapine in managing depression in patients after radical surgery for gastric cancer

Table 1 Depressed mood scores, mean ± SD

Group	Case	Before, SDS	After, SDS	Before, HAMD	After, HAMD	Before, BDI	After, BDI
Control	40	65.44 ± 3.18	53.27 ± 2.45a	21.16 ± 2.24	10.14 ± 2.12a	13.16 ± 1.24	6.12 ± 0.78a
Observation	40	65.72 ± 3.32	48.12 ± 2.96a	21.27 ± 2.12	6.36 ± 1.18a	13.20 ± 1.21	3.21 ± 0.54a
t		0.385	8.477	0.226	9.853	0.146	19.400
P value		0.701	< 0.001	0.822	< 0.001	0.884	< 0.001

^aP < 0.05. Comparison within the group before treatment.

SDS: Self-Rating Depression Scale; HAMD: Hamilton Depression Scale; BDI: Beck Depression Inventory.

Table 2 Neuroendocrine indicators, mean ± SD

Group	Case	Before, dopamine (pg/mL)	After, dopamine (pg/mL)	Before, 5-hydroxytryptamine (pg/mL)	After, 5-hydroxytryptamine (pg/mL)	Before, hydrocortisone (ng/mL)	After, hydrocortisone (ng/mL)
Control	40	40.12 ± 10.45	55.16 ± 12.24a	159.28 ± 40.18	182.15 ± 42.44a	212.72 ± 60.24	160.45 ± 31.78a
Observation	40	40.27 ± 10.32	76.18 ± 13.21a	160.12 ± 41.45	221.36 ± 45.52a	214.56 ± 62.48	121.54 ± 24.62a
t		0.065	7.382	0.092	3.985	0.134	6.121
P value		0.949	< 0.001	0.927	< 0.001	0.894	< 0.001

^aP < 0.05. Comparison within the group before treatment.

Table 3 Levels of the intestinal microbiota, mean ± SD, CFU/g

Group	Case	Before, Lactobacillus acidophilus	After, Lactobacillus acidophilus	Before, Bifidocaterium	After, Bifidocaterium	Before, Escherichia coli	After, Escherichia coli	Before, Enterococcus faecalis	After, Enterococcus faecalis
Control	40	6.32 ± 0.56	6.92 ± 0.48a	7.54 ± 0.52	8.21 ± 0.44a	10.27 ± 1.18	8.72 ± 0.80a	8.18 ± 0.82	7.12 ± 0.68a
Observation	40	6.35 ± 0.52	7.54 ± 0.42a	7.48 ± 0.56	9.12 ± 0.42a	10.21 ± 1.24	7.32 ± 0.64a	8.21 ± 0.78	6.08 ± 0.54a
t		0.248	6.148	0.497	9.462	0.222	8.643	0.168	7.575
P value		0.805	< 0.001	0.621	< 0.001	0.825	< 0.001	0.867	< 0.001

^aP < 0.05. Comparison within the group before treatment.

Table 4 Nutritional status, mean ± SD

Group	Case	Before, hemoglobin (g/L)	After, hemoglobin (g/L)	Before, blood albumin (g/L)	After, blood albumin (g/L)	Before, prealbumin (mg/L)	After, prealbumin (mg/L)
Control	40	90.12 ± 8.16	99.18 ± 6.32a	28.27 ± 3.42	32.12 ± 3.56a	245.72 ± 14.18	272.15 ± 10.44a
Observation	40	89.72 ± 8.24	110.24 ± 5.72a	28.14 ± 3.68	36.21 ± 3.12a	246.32 ± 12.56	298.42 ± 14.28a
t		0.218	8.206	0.164	5.465	0.200	9.392
P value		0.828	< 0.001	0.870	< 0.001	0.842	< 0.001

^aP < 0.05. Comparison within the group before treatment.

Table 5 Quality of life, mean ± SD

Group	Control	Observation	t	P value
Case	40	40
Before, dysphagia	11.12 ± 1.48	11.32 ± 1.56	0.588	0.558
After, dysphagia	8.24 ± 1.36a	6.16 ± 1.12a	7.467	< 0.001
Before, stomach pain	10.78 ± 1.24	10.86 ± 1.20	0.293	0.770
After, stomach pain	8.12 ± 1.18a	6.24 ± 0.96a	7.816	< 0.001
Before, dietary restriction	10.84 ± 1.16	10.78 ± 1.12	0.235	0.815
After, dietary restriction	8.20 ± 1.32a	6.54 ± 1.18a	5.930	< 0.001
Before, hiccups	8.72 ± 1.16	8.78 ± 1.20	0.227	0.821
After, hiccups	7.08 ± 0.72a	5.80 ± 0.64a	8.404	< 0.001
Before, anxiety	8.12 ± 1.18	8.16 ± 1.12	0.155	0.877
After, anxiety	6.72 ± 0.78a	5.24 ± 0.42a	10.566	< 0.001
Before, single entry	10.16 ± 1.24	10.12 ± 1.28	0.142	0.887
After, single entry	8.20 ± 1.12a	6.44 ± 1.10a	7.091	< 0.001
Before, total score	59.74 ± 7.46	60.02 ± 7.48	0.168	0.867
After, total score	46.56 ± 6.48a	36.42 ± 5.42a	7.591	< 0.001

^aP < 0.05. Comparison within the group before treatment.