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©The Author(s) 2025.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 113940
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.113940
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.113940
Table 1 Comparison of the baseline characteristics between the robotic liver resection and robotic intraoperative radiofrequency ablation groups before and after matching in de novo data, n (%)/median (interquartile range)
| Variable | Before PS matching | After PS matching | ||||
| RIO-RFA (n = 8) | R-LR (n = 49) | P value | RIO-RFA (n = 8) | R-LR (n = 8) | P value | |
| Age (years) | 71.5 (68.5-74.2) | 68.0 (62.0-77.0) | 0.621 | 71.5 (68.5-74.2) | 68.0 (58.8-77.5) | 0.713 |
| Male | 5 (62.5) | 31 (63.3) | 1 | 5 (62.5) | 5 (62.5) | 1 |
| Height (cm) | 164.5 (159.8-170.2) | 162.0 (157.0-168.0) | 0.4009 | 164.5 (159.8-170.2) | 162.0 (156.5-166.5) | 0.4613 |
| Weight (kg) | 66.5 (64.8-71.0) | 66.0 (53.0-75.0) | 0.5424 | 66.5 (64.8-71.0) | 60.0 (52.8-69.8) | 0.3998 |
| BMI (kg/m2) | 24.5 (23.0-25.4) | 23.4 (20.8-26.9) | 0.6116 | 24.5 (23.0-25.4) | 23.0 (21.1-24.8) | 0.3823 |
| HBV | 5 (62.5) | 33 (67.3) | 1 | 5 (62.5) | 6 (75.0) | 1 |
| HCV | 3 (37.5) | 13 (26.5) | 0.6735 | 3 (37.5) | 2 (25.0) | 1 |
| ICG-R15 < 10% | 1 (12.5) | 16 (32.7) | 0.4133 | 1 (12.5) | 2 (25.0) | 1 |
| Platelet (103/mL) | 127.5 (97.2-156.5) | 169.0 (135.0-215.0) | 0.0179 | 127.5 (97.2-156.5) | 135.5 (110.0-160.0) | 0.713 |
| Prothrombin time (s) | 10.8 (10.7-11.1) | 10.6 (10.3-11.1) | 0.295 | 10.8 (10.7-11.1) | 10.8 (10.4-11.0) | 0.5621 |
| AST (U/L) | 106.5 (79.0-460.8) | 244.0 (82.0-511.0) | 0.5972 | 106.5 (79.0-460.8) | 329.0 (174.0-857.5) | 0.1304 |
| ALT (U/L) | 112.0 (75.2-444.5) | 307.0 (120.0-532.0) | 0.2802 | 112.0 (75.2-444.5) | 366.5 (209.0-1018.8) | 0.1605 |
| AFP ≥ 100 ng/mL | 2 (25.0) | 8 (16.3) | 0.6194 | 2 (25.0) | 1 (12.5) | 1 |
| Bilirubin total (mg/dL) | 0.9 (0.8-1.1) | 0.8 (0.6-0.9) | 0.2478 | 0.9 (0.8-1.1) | 0.9 (0.8-1.0) | 1 |
| Albumin (g/dL) | 4.2 (4.0-4.6) | 4.4 (4.1-4.7) | 0.5567 | 4.2 (4.0-4.6) | 4.6 (4.4-4.7) | 0.2448 |
| ALBI (grade 1/2) | 6 (75.0)/2 (25.0) | 42 (85.7)/7 (14.3) | 0.599 | 6 (75.0)/2 (25.0) | 7 (87.5)/1 (12.5) | 1 |
| Child-Pugh (class A/B) | 7 (87.5)/1 (12.5) | 48 (98.0)/1 (2.0) | 0.2632 | 7 (87.5)/1 (12.5) | 8 (100.0)/0 (0.0) | 1 |
| T stage (1/2/3/4) | 6 (75.0)/1 (12.5)/0 (0.0)/1 (12.5) | 36 (73.5)/12 (24.5)/1 (2.0)/0 (0.0) | 0.0812 | 6 (75.0)/1 (12.5)/1(12.5) | 5 (62.5)/3 (37.5)/0 (0.0) | 0.3515 |
| Major tumor size (cm) | 1.6 (1.5-2.3) | 3.0 (1.8-4.5) | 0.0343 | 1.6 (1.5-2.3) | 2.1 (1.6-3.0) | 0.4589 |
| Aggregate tumor size (cm) | 1.6 (1.6-2.8) | 3.1 (2.1-4.5) | 0.071 | 1.6 (1.6-2.8) | 2.5 (1.9-3.0) | 0.5249 |
| Tumor numbers (1/2/3/4) | 5 (62.5)/1 (12.5)/1 (12.5)/1 (12.5) | 39 (79.6)/10 (30.4)/0 (0)/0 (0) | 0.0053 | 5 (62.5)/1 (12.5)/1(12.5)/1 (12.5) | 7 (87.5)/1 (12.5)/0 (0)/0 (0) | 0.5062 |
| Multi-tumors | 3 (37.5) | 10 (20.4) | 0.3653 | 3 (37.5) | 1 (12.5) | 0.5692 |
| BCLC (stage 0/A/B) | 3 (37.5)/4 (50.0)/1 (12.5) | 9 (18.4)/31 (63.3)/9 (18.4) | 0.4658 | 3 (37.5)/4 (50.0)/1(12.5) | 2 (25.0)/6 (75.0)/0 (0.0) | 0.4493 |
| Operation time (minutes) | 104.0 (68.8-128.8) | 175.0 (155.0-249.0) | 0.0002 | 104.0 (68.8-128.8) | 114.5 (93.0-182.8) | 0.2698 |
| SAS (score 2/3) | 5 (62.5)/3 (37.5) | 26 (53.1)/23 (46.9) | 0.7153 | 5 (62.5)/3 (37.5) | 4 (50.0)/4 (50.0) | 1 |
| Blood loss (mL) | 10.0 (10.0-10.0) | 350.0 (105.0-805.0) | 0.0003 | 10.0 (10.0-10.0) | 80.0 (10.0-117.5) | 0.1179 |
| Blood transfusion | 2 (25.0) | 31 (63.3)/18 (36.7) | 0.6993 | 2 (25.0) | 2 (25.0) | 1 |
| Complication | 1 (12.5) | 11 (22.4) | 1 | 1 (12.5) | 2 (25.0) | 1 |
| Hospital stays (days) | 9.5 (9.0-10.0) | 11.0 (9.0-14.0) | 0.3604 | 9.5 (9.0-10.0) | 10.5 (10.0-13.5) | 0.1151 |
Table 2 Comparison of the baseline characteristics between the robotic liver resection and robotic intraoperative radiofrequency ablation groups before and after matching in first recurrence data, n (%)/median (interquartile range)
| Variable | Before PS matching | After PS matching | ||||
| RIO-RFA (n = 8) | R-LR (n = 49) | P value | RIO-RFA (n = 8) | R-LR (n = 8) | P value | |
| Age (years) | 71.5 (62.8-75.0) | 68.0 (63.0-75.5) | 0.8608 | 71.5 (62.8-75.0) | 67.0 (63.0-74.0) | 0.7769 |
| Male | 14 (87.5) | 16 (80.0) | 0.6722 | 14 (87.5) | 13 (81.2) | 1 |
| Height (cm) | 164.0 (157.2-170.5) | 166.5 (158.8-169.2) | 0.8984 | 164.0 (157.2-170.5) | 167.5 (163.2-169.2) | 0.7196 |
| Weight (kg) | 64.5 (54.5-78.5) | 65.5 (61.5-75.0) | 0.7258 | 64.5 (54.5-78.5) | 71.2 (63.8-75.2) | 0.4063 |
| BMI (kg/m2) | 25.9 (20.7-27.0) | 26.2 (23.1-26.9) | 0.6906 | 25.9 (20.7-27.0) | 26.3 (24.5-27.0) | 0.534 |
| HBV | 8 (50.0) | 14 (70.0) | 0.3793 | 8 (50.0) | 10 (62.5) | 0.7216 |
| HCV | 4 (25.0) | 6 (30.0) | 1 | 4 (25.0) | 6 (37.5) | 0.7043 |
| ICG-R15 < 10% | 5 (31.2) | 7 (35.0) | 1 | 5 (31.2) | 3 (18.8) | 0.6851 |
| Platelet (103/mL) | 116.5 (89.5-151.5) | 123.0 (103.8-156.5) | 0.4737 | 116.5 (89.5-151.5) | 117.5 (98.0-145.0) | 0.91 |
| Prothrombin time (s) | 10.9 (10.5-11.0) | 10.5 (10.3-10.9) | 0.0867 | 10.9 (10.5-11.0) | 10.6 (10.4-10.9) | 0.2882 |
| AST (U/L) | 323.0 (155.2-1067.2) | 194.0 (126.0-323.0) | 0.1345 | 323.0 (155.2-1067.2) | 204.0 (126.8-323.0) | 0.2 |
| ALT (U/L) | 266.5 (174.0-762.0) | 274.5 (130.0-437.5) | 0.4544 | 266.5 (174.0-762.0) | 225.5 (130.0-384.2) | 0.3558 |
| AFP ≥ 100 ng/mL | 4 (25.0) | 5 (25.0) | 1 | 4 (25.0) | 4 (25.0) | 1 |
| Bilirubin total (mg/dL) | 1.0 (0.6-1.4) | 0.9 (0.7-1.1) | 0.3973 | 1.0 (0.6-1.4) | 0.9 (0.7-1.1) | 0.5962 |
| Albumin (g/dL) | 4.5 (4.0-4.6) | 4.3 (4.0-4.7) | 0.7736 | 4.5 (4.0-4.6) | 4.5 (4.1-4.7) | 0.4602 |
| ALBI (grade 1/2) | 12 (75.0)/4 (25.0) | 16 (80.0)/4 (20.0) | 1 | 12 (75.0)/4 (25.0) | 13 (81.2)/3 (18.8) | 1 |
| Child-Pugh (class A/B) | 12 (75.0)/4 (25.0) | 18 (90.0)/2 (10.0) | 0.3738 | 12 (75.0)/4 (25.0) | 14 (87.5)/2 (12.5) | 0.6539 |
| T stage (1/2/3/4) | 5 (31.2)/10 (62.5)/1 (6.2) | 13 (65.0)/6 (30.0)/1 (5.0) | 0.1248 | 5 (31.2)/10 (62.5)/1 (6.2) | 11 (68.8)/4 (25.0)/1 (6.2) | 0.0898 |
| Major tumor size (cm) | 2.3 (1.7-2.7) | 1.9 (1.5-2.8) | 0.5133 | 2.3 (1.7-2.7) | 1.9 (1.3-2.2) | 0.2993 |
| Aggregate tumor size (cm) | 3.3 (2.4-5.3) | 2.0 (1.8-3.4) | 0.0581 | 3.3 (2.4-5.3) | 1.9 (1.6-2.7) | 0.0184 |
| Tumor numbers (1/2/3/4/5) | 7 (43.8)/4 (25.0)/3 (18.8)/1 (6.2)/1 (6.2) | 13 (65.0)/5 (25.0)/2 (10.0)/0 (0)/0 (0) | 0.4463 | 7 (43.8)/4 (25.0)/3 (18.8)/1 (6.2)/1 (6.2) | 11 (68.8)/3 (18.8)/2 (12.5)/0 (0)/0 (0) | 0.5198 |
| Multi-tumors | 9 (56.2) | 7 (35.0) | 0.3485 | 9 (56.2) | 5 (31.2) | 0.285 |
| BCLC (stage 0/A/B) | 1 (6.2)/12 (75.0)/3 (18.8) | 6 (30.0)/12 (60.0)/2 (10.0) | 0.1856 | 1 (6.2)/12 (75.0)/3 (18.8) | 6 (37.5)/9 (56.2)/1 (6.2) | 0.0821 |
| Operation time (minutes) | 109.5 (100.0-175.5) | 167.5 (128.5-197.2) | 0.1043 | 109.5 (100.0-175.5) | 164.5 (128.5-176.0) | 0.1998 |
| SAS (score 2/3) | 9 (56.2)/7 (43.8) | 12 (60.0)/8 (40.0) | 1 | 9 (56.2)/7 (43.8) | 11 (68.8)/5 (31.2) | 0.715 |
| Blood loss (mL) | 10.0 (10.0-55.0) | 175.0 (77.5-326.2) | 0.0046 | 10.0 (10.0-55.0) | 175.0 (10.0-266.2) | 0.0174 |
| Blood transfusion | 5 (31.2) | 7 (35.0) | 1 | 5 (31.2) | 5 (31.2) | 1 |
| Complication | 5 (31.2) | 2 (10.0) | 0.2036 | 5 (31.2) | 2 (12.5) | 0.3944 |
| Hospital stays (days) | 8.0 (7.0-11.0) | 9.0 (7.8-12.0) | 0.3857 | 8.0 (7.0-11.0) | 9.0 (7.8-10.5) | 0.5055 |
Table 3 Univariate and multivariate analysis of prognostic factors for overall survival in de novo data
| Variable | Before PS matching (n = 57) | After PS matching (n = 16) | ||||||
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
| Treatment | 0.61 (0.18-2.14) | 0.443 | 0.58 (0.10-3.47) | 0.548 | ||||
| Age | 1.03 (0.98-1.08) | 0.193 | 1.04 (0.99-1.10) | 0.150 | 1.15 (0.97-1.37) | 0.107 | 1.63 (0.74-3.56) | 0.224 |
| Gender | 2.55 (1.00-6.49) | 0.050 | 4.98 (1.03-24.06) | 0.046 | 0.57 (0.06-5.12) | 0.613 | ||
| HBV | 0.83 (0.32-2.15) | 0.706 | 0.81 (0.13-4.89) | 0.818 | ||||
| HCV | 0.70 (0.23-2.13) | 0.528 | 0.36 (0.04-3.27) | 0.363 | ||||
| ICG-R15 < 10% | 0.62 (0.20-1.89) | 0.403 | 0.00 (0.00-inf) | 0.995 | ||||
| Platelet | 1.00 (0.99-1.00) | 0.458 | 1.00 (0.98-1.02) | 0.988 | ||||
| Prothrombin time | 1.09 (0.74-1.59) | 0.674 | 2.80 (0.69-11.37) | 0.151 | 6.42 (0.17-249.92) | 0.319 | ||
| AST | 1.00 (1.00-1.00) | 0.973 | 1.00 (1.00-1.00) | 0.772 | ||||
| ALT | 1.00 (1.00-1.00) | 0.869 | 1.00 (1.00-1.00) | 0.594 | ||||
| AFP ≥ 100 ng/mL | 1.15 (0.33-3.99) | 0.823 | 0.00 (0.00-inf) | 0.996 | ||||
| Bilirubin total | 0.48 (0.09-2.71) | 0.409 | 0.30 (0.00-22.14) | 0.584 | ||||
| Albumin | 0.55 (0.20-1.53) | 0.252 | 0.12 (0.01-1.48) | 0.098 | 31.48 (0.00-3.6 × 109) | 0.716 | ||
| ALBI | 1.56 (0.51-4.73) | 0.435 | 6.28 (0.86-45.89) | 0.07 | 30.75 (0.00-8.2 × 106) | 0.591 | ||
| Child-Pugh | 0.00 (0.00-inf) | 0.996 | 0.00 (0.00-inf) | 0.996 | ||||
| T stage | 1.23 (0.62-2.42) | 0.554 | 0.54 (0.09-3.09) | 0.489 | ||||
| Major tumor size | 1.18 (0.97-1.44) | 0.106 | 1.40 (0.53-3.70) | 0.497 | 1.64 (0.58-4.62) | 0.346 | ||
| Aggregate tumor size | 1.16 (0.96-1.42) | 0.132 | 0.95 (0.38-2.37) | 0.905 | 1.28 (0.46-3.62) | 0.638 | ||
| Tumor numbers | 0.88 (0.34-2.32) | 0.800 | 0.00 (0.00-inf) | 0.996 | ||||
| BCLC | 1.59 (0.72-3.49) | 0.249 | 0.71 (0.15-3.42) | 0.67 | ||||
| SAS | 0.95 (0.38-2.41) | 0.917 | 2.26 (0.38-13.60) | 0.373 | ||||
| Complication | 1.07 (0.31-3.72) | 0.911 | 6.28 (0.86-45.89) | 0.07 | 0.05 (0.00-2.7 × 1012) | 0.853 | ||
Table 4 Univariate and multivariate analysis of prognostic factors for recurrence-free survival in de novo data
| Variable | Before PS matching (n = 36) | After PS matching (n = 32) | ||||||
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
| Treatment | 0.13 (0.02-0.66) | 0.014 | 1.15 (0.01-264.01) | 0.960 | 0.16 (0.03-0.83) | 0.029 | 0.92 (0.00-299.08) | 0.977 |
| Age | 1.00 (0.95-1.07) | 0.886 | 1.01 (0.95-1.08) | 0.782 | ||||
| Gender | 0.54 (0.07-4.30) | 0.556 | 0.54 (0.07-4.38) | 0.565 | ||||
| HBV | 1.26 (0.31-5.08) | 0.742 | 1.62 (0.40-6.51) | 0.498 | ||||
| HCV | 0.67 (0.14-3.22) | 0.614 | 0.53 (0.11-2.59) | 0.436 | ||||
| ICG-R15 < 10% | 1.82 (0.49-6.80) | 0.373 | 3.35 (0.88-12.70) | 0.076 | 100.80 (0.28-36753.83) | 0.125 | ||
| Platelet | 1.00 (0.99-1.01) | 0.514 | 1.00 (0.99-1.01) | 0.872 | ||||
| Prothrombin time | 1.60 (1.11-2.30) | 0.011 | 16.45 (0.51-528.83) | 0.114 | 1.55 (1.09-2.20) | 0.015 | 3.06 (0.10-93.96) | 0.522 |
| AST | 1.00 (1.00-1.00) | 0.127 | 1.00 (0.99-1.01) | 0.970 | 1.00 (1.00-1.00) | 0.180 | 1.00 (0.99-1.01) | 0.643 |
| ALT | 1.00 (1.00-1.00) | 0.955 | 1.00 (1.00-1.00) | 0.882 | ||||
| AFP ≥ 100 ng/mL | 2.36 (0.63-8.84) | 0.203 | 2.41 (0.64-9.01) | 0.191 | 1.65 (0.07-36.92) | 0.753 | ||
| Bilirubin total | 1.15 (0.24-5.58) | 0.861 | 0.97 (0.19-5.03) | 0.970 | ||||
| Albumin | 0.41 (0.12-1.38) | 0.150 | 26.60 (0.34-2088.41) | 0.141 | 0.41 (0.13-1.25) | 0.115 | 7.23 (0.07-799.58) | 0.410 |
| ALBI | 1.18 (0.25-5.71) | 0.834 | 1.31 (0.27-6.34) | 0.738 | ||||
| Child-Pugh | 2.08 (0.43-10.07) | 0.362 | 1.77 (0.37-8.54) | 0.479 | ||||
| T stage | 3.79 (1.16-12.31) | 0.027 | 0.09 (0.00-4.55) | 0.225 | 3.87 (1.22-12.25) | 0.021 | 0.31 (0.01-18.91) | 0.577 |
| Major tumor size | 1.35 (0.83-2.20) | 0.228 | 1.51 (0.93-2.43) | 0.095 | 3.89 (0.07-211.13) | 0.505 | ||
| Aggregate tumor size | 1.30 (1.05-1.61) | 0.016 | 1.57 (0.70-3.56) | 0.276 | 1.32 (1.08-1.61) | 0.007 | 1.33 (0.38-4.66) | 0.652 |
| Tumor numbers | 1.70 (0.99-2.91) | 0.055 | 4.65 (0.77-27.97) | 0.093 | 1.62 (0.95-2.76) | 0.076 | 12.29 (0.28-534.39) | 0.192 |
| BCLC | 2.87 (0.88-9.38) | 0.082 | 26.75 (0.89-803.48) | 0.058 | 3.70 (1.10-12.41) | 0.034 | 0.99 (0.00-395.47) | 0.997 |
| SAS | 0.80 (0.20-3.20) | 0.749 | 1.00 (0.25-4.01) | 0.998 | ||||
| Complication | 7.29 (1.94-27.33) | 0.003 | 142.17 (0.37-55319.72) | 0.103 | 6.14 (1.64-23.03) | 0.007 | 0.42 (0.00-83.99) | 0.750 |
Table 5 Univariate and multivariate analysis of prognostic factors for overall survival in first recurrence data
| Variable | Before PS matching (n = 57) | After PS matching (n = 16) | ||||||
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
| Treatment | 1.34 (0.41-4.43) | 0.631 | 1.45 (0.32-6.52) | 0.626 | ||||
| Age | 1.01 (0.98-1.05) | 0.441 | 1.14 (1.00-1.29) | 0.056 | 1.04 (0.81-1.32) | 0.769 | ||
| Gender | 1.17 (0.55-2.47) | 0.679 | 0.29 (0.03-2.40) | 0.249 | ||||
| HBV | 0.50 (0.24-1.04) | 0.064 | 0.52 (0.24-1.11) | 0.090 | 0.20 (0.04-0.95) | 0.042 | 0.06 (0.00-1.45) | 0.084 |
| HCV | 1.38 (0.63-3.03) | 0.415 | 2.03 (0.45-9.18) | 0.356 | ||||
| ICG-R15 < 10% | 0.48 (0.20-1.18) | 0.109 | 0.73 (0.27-1.99) | 0.533 | 0.00 (0.00-inf) | 0.994 | ||
| Platelet | 0.99 (0.99-1.00) | 0.050 | 1.00 (0.99-1.00) | 0.516 | 1.00 (0.99-1.01) | 0.778 | 1.12 (0.08-15.00) | 0.930 |
| Prothrombin time | 1.85 (1.06-3.23) | 0.031 | 1.31 (0.77-2.25) | 0.319 | 3.92 (0.97-15.91) | 0.056 | ||
| AST | 1.00 (1.00-1.00) | 0.526 | 1.00 (1.00-1.00) | 0.917 | ||||
| ALT | 1.00 (1.00-1.00) | 0.639 | 1.00 (1.00-1.00) | 0.973 | ||||
| AFP ≥ 100 ng/mL | 0.69 (0.24-1.99) | 0.493 | 0.00 (0.00-inf) | 0.994 | ||||
| Bilirubin total | 3.31 (0.74-14.89) | 0.118 | 2.44 (0.42-14.28) | 0.321 | 7.55 (0.24-234.20) | 0.249 | ||
| Albumin | 0.47 (0.20-1.09) | 0.079 | 0.65 (0.25-1.71) | 0.383 | 0.44 (0.07-2.81) | 0.389 | ||
| ALBI | 1.70 (0.69-4.18) | 0.249 | 2.08 (0.40-10.81) | 0.383 | ||||
| Child-Pugh | 0.95 (0.13-7.01) | 0.962 | 0.00 (0.00-inf) | 0.995 | ||||
| T stage | 0.96 (0.52-1.77) | 0.899 | 0.74 (0.24-2.28) | 0.602 | ||||
| Major tumor size | 1.05 (0.89-1.25) | 0.539 | 1.11 (0.49-2.54) | 0.802 | ||||
| Aggregate tumor size | 1.06 (0.90-1.25) | 0.457 | 1.15 (0.50-2.66) | 0.747 | ||||
| Tumor numbers | 1.11 (0.60-2.04) | 0.740 | 0.59 (0.14-2.56) | 0.479 | ||||
| BCLC | 1.09 (0.60-1.97) | 0.786 | 0.51 (0.13-1.92) | 0.316 | ||||
| SAS | 1.73 (0.84-3.55) | 0.137 | 1.25 (0.57-2.75) | 0.574 | 4.70 (0.90-24.48) | 0.066 | 0.94 (0.04-22.31) | 0.972 |
| Complication | 0.67 (0.23-1.93) | 0.459 | 2.08 (0.40-10.81) | 0.383 | ||||
Table 6 Univariate and multivariate analysis of prognostic factors for recurrence-free survival in first recurrence data
| Variable | Before PS matching (n = 36) | After PS matching (n = 32) | ||||||
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
| Treatment | 0.32 (0.13-0.81) | 0.016 | 0.29 (0.09-0.97) | 0.043 | 0.39 (0.15-1.00) | 0.051 | 0.46 (0.13-1.61) | 0.226 |
| Age | 0.99 (0.95-1.03) | 0.586 | 1.00 (0.96-1.05) | 0.847 | ||||
| Gender | 2.77 (0.97-7.95) | 0.058 | 6.60 (1.79-24.32) | 0.004 | 3.22 (1.12-9.28) | 0.030 | 6.81 (1.98-23.41) | 0.002 |
| HBV | 0.61 (0.25-1.47) | 0.267 | 0.74 (0.30-1.82) | 0.508 | ||||
| HCV | 1.04 (0.40-2.72) | 0.937 | 0.88 (0.33-2.33) | 0.795 | ||||
| ICG-R15 < 10% | 1.22 (0.48-3.07) | 0.675 | 2.42 (0.88-6.66) | 0.088 | 1.33 (0.37-4.84) | 0.660 | ||
| Platelet | 0.99 (0.99-1.00) | 0.137 | 0.99 (0.98-1.00) | 0.129 | 1.00 (0.99-1.00) | 0.321 | ||
| Prothrombin time | 1.35 (0.95-1.92) | 0.098 | 1.21 (0.88-1.66) | 0.235 | 1.29 (0.90-1.87) | 0.167 | 1.28 (0.91-1.80) | 0.153 |
| AST | 1.00 (1.00-1.00) | 0.418 | 1.00 (1.00-1.00) | 0.672 | ||||
| ALT | 1.00 (1.00-1.00) | 0.74 | 1.00 (1.00-1.00) | 0.782 | ||||
| AFP ≥ 100 ng/mL | 2.09 (0.82-5.32) | 0.12 | 2.60 (0.72-9.44) | 0.145 | 2.69 (1.04-6.97) | 0.041 | 2.08 (0.54-8.01) | 0.285 |
| Bilirubin total | 1.72 (0.63-4.70) | 0.293 | 1.26 (0.43-3.70) | 0.675 | ||||
| Albumin | 0.69 (0.24-1.98) | 0.491 | 0.63 (0.23-1.73) | 0.369 | ||||
| ALBI | 1.44 (0.52-3.97) | 0.482 | 1.28 (0.42-3.88) | 0.66 | ||||
| Child-Pugh | 1.32 (0.38-4.53) | 0.658 | 1.15 (0.33-3.98) | 0.824 | ||||
| T stage | 1.36 (0.60-3.08) | 0.455 | 1.34 (0.59-3.04) | 0.482 | ||||
| Major tumor size | 1.01 (0.67-1.53) | 0.951 | 1.08 (0.68-1.71) | 0.743 | ||||
| Aggregate tumor size | 1.08 (0.89-1.32) | 0.436 | 1.12 (0.93-1.35) | 0.214 | ||||
| Tumor numbers | 1.30 (0.85-1.98) | 0.224 | 1.30 (0.87-1.95) | 0.202 | ||||
| BCLC | 1.08 (0.50-2.31) | 0.843 | 1.41 (0.64-3.14) | 0.397 | ||||
| SAS | 0.74 (0.29-1.85) | 0.514 | 1.02 (0.40-2.60) | 0.967 | ||||
| Complication | 4.20 (1.65-10.70) | 0.003 | 3.62 (1.09-11.96) | 0.034 | 3.78 (1.46-9.75) | 0.006 | 3.08 (0.76-12.44) | 0.114 |
Table 7 Log-rank test results comparing overall survival between unstratified and risk-stratified subgroups of the robotic liver resection group in the de novo group prior to propensity score matching
| Gender | Major tumor size | Aggregate tumor size | |
| Low risk vs unstratified R-LR | 0.208 | 0.079 | 0.139 |
| High risk vs unstratified R-LR | 0.069 | 0.370 | 0.281 |
| Low risk vs unstratified RIO-RFA | 0.068 | 0.011 | 0.036 |
| High risk vs unstratified RIO-RFA | 0.595 | 0.867 | 0.971 |
Table 8 Log-rank test results comparing overall survival between unstratified and risk-stratified subgroups of the robotic liver resection group in the first recurrence group after propensity score matching
| Aggregate tumor size | Complication | |
| Low risk vs unstratified R-LR | 0.320 | 0.145 |
| High risk vs unstratified R-LR | < 0.001 | < 0.001 |
| Low risk vs unstratified RIO-RFA | 0.188 | 0.357 |
| High risk vs unstratified RIO-RFA | 0.057 | 0.122 |
Table 9 Log-rank test results comparing recurrence-free survival between unstratified and risk-stratified subgroups of the robotic liver resection group in the de novo group prior to propensity score matching
| Platelet | Prothrombin time | |
| Low risk vs unstratified R-LR | 0.151 | 0.232 |
| High risk vs unstratified R-LR | 0.029 | 0.171 |
| Low risk vs unstratified RIO-RFA | 0.718 | 0.805 |
| High risk vs unstratified RIO-RFA | 0.106 | 0.240 |
Table 10 Log-rank test results comparing recurrence-free survival between unstratified and risk-stratified subgroups of the robotic intraoperative radiofrequency ablation group in the first recurrence group after propensity score matching
| Platelet | OP time | Complication | |
| Low risk vs unstratified R-LR | 0.971 | 0.844 | 0.343 |
| High risk vs unstratified R-LR | < 0.001 | < 0.001 | < 0.001 |
| Low risk vs unstratified RIO-RFA | 0.143 | 0.216 | 0.428 |
| High risk vs unstratified RIO-RFA | 0.090 | 0.230 | 0.159 |
- Citation: Peng CM, Lin SC, Cheng YY, Cheng TC, Hsieh CL, Hsieh CH, Hsieh MF, Liao CH, Liu MC, Liu YJ. Outcomes of robotic liver resection and intraoperative radiofrequency ablation for hepatocellular carcinoma in posterior segments VII and VIII. World J Gastrointest Surg 2025; 17(12): 113940
- URL: https://www.wjgnet.com/1948-9366/full/v17/i12/113940.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v17.i12.113940
