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Randomized Clinical Trial
Copyright ©The Author(s) 2025.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 113364
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.113364
Table 1 Between-group comparisons of laboratory parameters (mean ± SD, ng/L)
Group
Observation group (n = 28)
Control group (n = 27)
t value
P value
IL-6Before intervention35.18 ± 9.6735.72 ± 9.430.1000.835
After intervention9.81 ± 2.19a32.35 ± 9.91a11.7450.000
IL-4Before intervention6.58 ± 0.316.63 ± 0.080.8120.420
After intervention0.74 ± 0.06a4.02 ± 0.74a23.3830.000
IL-2Before intervention4.25 ± 0.824.53 ± 0.671.3840.172
After intervention0.55 ± 0.13a1.96 ± 0.21a30.0600.000
IL-17ABefore intervention10.29 ± 0.5610.34 ± 0.230.4300.669
After intervention3.25 ± 1.03a8.15 ± 0.84a19.2940.000
IFN-γBefore intervention5.36 ± 0.495.51 ± 0.730.8980.373
After intervention0.69 ± 0.17a2.58 ± 0.28a30.3850.000
TNF-αBefore intervention3.07 ± 0.513.24 ± 0.181.6360.108
After intervention1.71 ± 0.42a2.73 ± 0.33a9.9900.000
IL-10Before intervention6.37 ± 0.256.51 ± 0.790.8930.376
After intervention1.31 ± 0.32a3.59 ± 0.91a12.4580.000
Table 2 Within-group comparisons of cytokine levels (mean ± SD, ng/L)
Group
Cytokine
Before intervention
After intervention
t value
P value
Observation group (n = 28)IL-635.18 ± 9.679.81 ± 2.1913.5400.000
IL-46.58 ± 0.310.74 ± 0.0697.8690.000
IL-24.25 ± 0.820.55 ± 0.1323.5820.000
IL-17A10.29 ± 0.563.25 ± 1.0331.7750.000
IFN-γ5.36 ± 0.490.69 ± 0.1747.6450.000
TNF-α3.07 ± 0.511.71 ± 0.4210.8930.000
IL-106.37 ± 0.251.31 ± 0.3265.9340.000
Control group (n = 27)IL-635.72 ± 9.4332.35 ± 9.911.2800.206
IL-46.63 ± 0.084.02 ± 0.7418.2210.000
IL-24.53 ± 0.671.96 ± 0.2119.0190.000
IL-17A10.34 ± 0.238.15 ± 0.8413.0660.000
IFN-γ5.51 ± 0.732.58 ± 0.2819.4730.000
TNF-α3.24 ± 0.182.73 ± 0.337.0500.000
IL-106.51 ± 0.793.59 ± 0.9112.5910.000
Table 3 Between-group comparisons of nutritional status
Group
Observation group (n = 28)
Control group (n = 27)
χ2/t
P value
CONUT, n (%)Before intervention> 2 points15 (53.57)21 (77.78)3.5620.059
≤ 2 points13 (46.43)6 (22.22)
After intervention> 2 points3 (10.71)18 (66.67)18.2320.000
≤ 2 points25 (89.29)9 (33.33)
PA (mean ± SD, mg/L)Before intervention265.28 ± 52.31265.74 ± 52.860.0320.974
After intervention141.56 ± 37.38a260.97 ± 61.84a8.7030.000
Table 4 Within-group comparisons of nutritional status
Group
Indicator
Before intervention
After intervention
t/χ2
P value
Observation group (n = 28)CONUT > 2, n (%)15 (53.57)3 (10.71)11.790< 0.001
PA (mean ± SD, mg/L)265.28 ± 52.31141.56 ± 37.38a10.183< 0.001
Control group (n = 27)CONUT > 2, n (%)21 (77.78)18 (66.67)0.8310.362
PA (mean ± SD, mg/L)265.74 ± 52.86260.97 ± 61.84a0.3100.758
Table 5 Comparison of gastrointestinal function recovery time (mean ± SD)
Group
Exhaust time (hour)
Recovery time of bowel sounds (day)
Improvement time of abdominal distension (day)
Observation group (n = 28)31.97 ± 4.352.84 ± 0.573.37 ± 0.43
Control group (n = 27)45.71 ± 4.783.81 ± 0.684.31 ± 0.56
t value11.1575.7416.998
P value0.0000.0000.000