Postoperative body weight change and its influencing factors in patients with gastric cancer

Table 1 Characteristics of study participants, n (%)

Variable		n = 121
Gender	Male	80 (66.1)
	Female	41 (33.9)
Age	≥ 65 years	61 (50.4)
	< 65 years	60 (49.6)
Occupation	Farmer	56 (46.3)
	Worker	13 (10.7)
	Retired	32 (26.5)
	Others	20 (16.5)
Residence	Country	55 (45.5)
	Town	30 (24.8)
	City	36 (29.7)
Education level	Elementary or below	57 (47.1)
	Middle school	31 (25.6)
	High school	17 (14.1)
	College or above	16 (13.2)
Religion	No	111 (91.7)
	Yes	10 (8.3)
Marriage status	Married	111 (91.7)
	Single or divorced or widowed	10 (8.3)
Living condition	Solitude	11 (9.1)
	Live with relatives	110 (90.9)
Monthly household income (RMB)	< ¥1000	11 (9.1)
	¥1000-¥3000	31 (25.6)
	¥3000-¥5000	33 (27.3)
	¥5000-¥10000	34 (28.1)
	≥ ¥10000	12 (9.9)
Payment method for medical expenses	Medical insurance	51 (42.1)
	Rural and urban health insurance	70 (57.9)
TNM stage	0	1 (0.8)
	I	45 (37.2)
	II	30 (24.8)
	III	45 (37.2)
	IV	0 (0.0)
Operation mode	Laparoscopy	76 (62.8)
	Open surgery	45 (37.2)
Gastrectomy type	Total gastrectomy	48 (39.7)
	Partial gastrectomy	73 (60.3)
Postoperative complications	No	95 (78.5)
	Yes	26 (21.5)
Perioperative chemotherapy	No	38 (31.4)
	Yes	83 (68.6)
Preoperative chemotherapy	No	95 (78.5)
	Yes	26 (21.5)
Concomitant chronic diseases	None	67 (55.4)
	1	34 (28.1)
	2 or more	20 (16.5)
Preoperative BMI (kg/m2)	< 18.50	10 (8.3)
	18.50-22.99	62 (51.2)
	23.00-24.99	24 (19.8)
	≥ 25.00	25 (20.7)

TNM: Tumor-node-metastasis; BMI: Body mass index.

Table 2 Time-effect analysis of weight changes in patients with gastric cancer from 0 to 6 mo after gastrectomy

Variable	β	SE	95%CI		Wald χ2	P value
			Lower	Upper
Time point					331.407	< 0.001
T3	-8.834	0.525	-9.862	-7.805	283.228	< 0.001
T2	-6.818	0.399	-7.600	-6.035	291.886	< 0.001
T1	-3.891	0.277	-4.435	-3.347	196.749	< 0.001
T0	-

β: Partial regression coefficient; SE: Standard error; CI: Confidence interval; T0: Before gastrectomy; T1: 1 mo after gastrectomy; T2: 3 mo after gastrectomy; T3: 6 mo after gastrectomy.

Table 3 Univariate analysis of influencing factors of dynamic changes in body weight in patients with gastric cancer within 6 mo after gastrectomy

Variable	β	SE	95%CI		Wald χ2	P value
			Lower	Upper
Age
≥ 65 years	-1.781	1.771	-5.252	1.691	1.011	0.315
< 65 years	-
Gender
Male	13.225	1.334	10.610	15.840	98.260	< 0.001b
Female	-
Occupation					7.748	0.052
Farmer	-4.684	2.532	-9.647	0.280	3.421	0.064
Worker	0.449	2.824	-5.086	5.985	0.025	0.874
Retired	-0.504	2.833	-6.058	5.049	0.032	0.859
Others	-
Residence					4.663	0.097
City	3.932	2.115	-0.213	8.077	3.457	0.063
Town	3.546	2.142	-0.652	7.743	2.741	0.098
Country	-
Education level					1.888	0.596
College or above	3.164	2.818	-2.359	8.687	1.261	0.262
High school	2.479	2.792	-2.994	7.952	0.788	0.375
Middle school	1.797	2.118	-2.355	5.949	0.720	0.396
Primary school	-
Religion
Yes	-8.611	3.148	-14.781	-2.441	7.482	0.006b
No	-
Marriage status
Single or divorced or widowed	-11.109	2.451	-15.912	-6.306	20.549	< 0.001b
Married	-
Living condition
Live with relatives	-1.543	3.945	-9.275	6.189	0.153	0.696
Solitude	-
Monthly household income (RMB)					2.758	0.599
≥ ¥10000	1.083	4.743	-8.214	10.380	0.052	0.819
¥5000-¥10000	-3.732	3.863	-11.303	3.838	0.934	0.334
¥3000-¥5000	-0.866	3.736	-8.188	6.456	0.054	0.817
¥1000-¥3000	-1.321	3.875	-8.915	6.274	0.116	0.733
< ¥1000	-
Payment method for medical expenses
Medical insurance	3.934	1.719	0.565	7.303	5.237	0.022a
Rural and urban health insurance	-
Concomitant chronic diseases					3.391	0.183
2 or more	3.433	2.739	-1.935	8.802	1.571	0.210
1	3.187	1.989	-0.711	7.085	2.567	0.109
None	-
TNM stage					3.234	0.198
III	-1.864	1.980	-5.744	2.017	0.886	0.347
II	2.471	2.337	-2.110	7.052	1.118	0.290
I	-
Operation mode
Open surgery	2.018	1.856	-1.620	5.656	1.182	0.277
Laparoscopy	-
Gastrectomy type
Partial gastrectomy	2.141	1.789	-1.366	5.649	1.432	0.231
Total gastrectomy	-
Postoperative complications
Yes	-1.535	2.346	-6.132	3.063	0.428	0.513
No	-
Perioperative chemotherapy
Yes	0.777	1.890	-2.927	4.481	0.169	0.681
No	-
Preoperative chemotherapy
Yes	2.842	2.303	-1.672	7.356	1.523	0.217
No	-
Preoperative BMI (kg/m2)					168.996	< 0.001b
≥ 25.00 kg/m2	25.416	2.187	21.130	29.702	135.101	< 0.001b
23.00-24.99 kg/m2	19.058	2.038	15.063	23.054	87.417	< 0.001b
18.50-22.99 kg/m2	10.892	1.912	7.145	14.639	32.462	< 0.001b
< 18.50 kg/m2	-
Significant psychological distress
Yes	-1.050	0.405	-1.844	-0.256	6.715	0.010a
No	-

^aP < 0.05.

^bP < 0.01.

TNM: Tumor-node-metastasis; BMI: Body mass index; β: Partial regression coefficient; SE: Standard error; CI: Confidence interval.

Table 4 Multivariate analysis of factors influencing dynamic changes in body weight in patients with gastric cancer from 0 to 6 mo after gastrectomy

Variable	β	SE	95%CI		Wald χ2	P value
			Lower	Upper
Intercept	41.943	2.052	37.920	45.966	417.624	< 0.001b
Gender
Male	4.262	2.052	0.240	8.285	4.313	0.038a
Female	-
Religion
Yes	-6.844	2.052	-10.867	-2.821	11.119	0.001b
No	-
Marriage status
Single or divorced or widowed	-2.559	2.957	-8.354	3.237	0.749	0.387
Married	-
Payment method for medical expenses
Medical insurance	0.309	1.831	-3.279	3.897	0.029	0.866
Rural and urban health insurance	-
Preoperative BMI					1288.795	< 0.001b
≥ 25.00 kg/m2	14.685	2.425	9.932	19.438	36.669	< 0.001b
23.00-24.99 kg/m2	12.098	2.052	8.075	16.120	34.743	< 0.001b
18.50-22.99 kg/m2	5.913	1.320	3.326	8.500	20.065	< 0.001b
< 18.50 kg/m2	-
Significant psychological distress
Yes	2.490	0.624	1.266	3.714	15.905	< 0.001b
No	-

^aP < 0.05.

^bP < 0.01.

BMI: Body mass index; β: Partial regression coefficient; SE: Standard error; CI: Confidence interval.