Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers

doi:10.4240/wjgs.v16.i5.1344

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 5

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (1284)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-4) series, Tables (1-2) series.

Item

Count

PDF

HTML

612

Figures (1-4)

149

Tables (1-2)

170

Sum=974

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

184

Sum=255

May 27, 2024 (publication date) through Jan 11, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Surgery

ISSN

1948-9366

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Surg. May 27, 2024; 16(5): 1344-1353
Published online May 27, 2024. doi: 10.4240/wjgs.v16.i5.1344

Table 1 Baseline information between the development and validation cohorts, n (%)

Characteristics	Development (2473)	Validation (1056)	P value
Age, yr	63.1 ± 12.0	61.7 ± 12.3	0.002^a
Sex			0.930
Male	1448 (58.4)	620 (59.1)
Female	1025 (41.6)	436 (40.9)
BMI, kg/m²	22.6 ± 3.2	22.8 ± 3.2	0.180
Smoking	942 (37.0)	395 (37.9)	0.700
Drinking	767 (30.8)	310 (29.8)	0.327
Hypertension	649 (25.1)	257 (25.4)	0.235
T2DM	311 (11.5)	123 (11.5)	0.442
CHD	98 (4.3)	52 (4.8)	0.195
Tumor location			0.217
Colon	1166 (47.3)	582 (46.9)
Rectum	1307 (52.7)	474 (53.1)
TNM stage			0.802
I	490 (18.9)	215 (18.4)
II	1067 (39.9)	443 (40.4)
III	916 (35.6)	398 (36.6)
Tumor size			0.705
< 5 cm	1442 (60.1)	623 (60.9)
≥ 5 cm	1031 (39.9)	433 (39.1)
CEA			0.053
Normal	1562 (63.2)	703 (66.6)
Abnormal	911 (36.8)	353 (33.4)
CA199			0.823
Normal	1973 (79.8)	839 (79.5)
Abnormal	500 (20.2)	217 (20.5)
AFP			0.105
Normal	2366 (95.7)	997 (94.4)
Abnormal	107 (4.3)	59 (5.6)
Surgical time, min	224.5 ± 78.3	224.6 ± 78.3	0.967

^aP < 0.05.

T2DM: Type 2 diabetes mellitus; BMI: Body mass index; CHD: Chronic heart disease; TNM: Tumor node metastasis; AFP: Alpha fetoprotein; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 19-9.

Table 2 Univariate and multivariate analysis of overall survival

Risk factors	Univariate analysis		Multivariate analysis
Risk factors	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)	1.045 (1.037-1.055)	< 0.01^a	1.042 (1.033-1.051)	< 0.01^a
Sex (male/female)	0.931 (0.770-1.126)	0.461
BMI (kg/m²)	0.952 (0.924-0.981)	0.001^a	0.980 (0.952-1.008)	0.161
T2DM (yes/no)	1.231 (0.938-1.617)	0.134
Tumor location (colon/ rectum)	1.179 (0.979-1.421)	0.083
Tumor stage (III/II/I)	2.105 (1.817-2.438)	< 0.01^a	1.938 (1.665-2.255)	< 0.01^a
Smoking (yes/no)	0.964 (0.795-1.168)	0.706
Drinking (yes/no)	0.884 (0.718-1.089)	0.248
Hypertension (yes/no)	0.926 (0.743-1.154)	0.493
Tumor size (≥ 5 cm/< 5 cm)	1.426 (1.184-1.718)	< 0.01^a	1.117 (0.923-1.351)	0.255
CEA (abnormal/normal)	2.185 (1.812-2.633)	< 0.01^a	1.393 (1.137-1.707)	0.001^a
AFP (abnormal/normal)	1.108 (0.715-1.718)	0.645
CA-199 (abnormal/normal)	2.646 (2.185-3.204)	< 0.01^a	1.984 (1.614-2.438)	< 0.01^a
Surgical time, min	1.001 (1.000-1.002)	0.069

^aP < 0.05.

BMI: Body mass index; T2DM: Type 2 diabetes mellitus; AFP: Alpha fetoprotein; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 19-9.

Citation: Diao YH, Rao SQ, Shu XP, Cheng Y, Tan C, Wang LJ, Peng D. Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers. World J Gastrointest Surg 2024; 16(5): 1344-1353
URL: https://www.wjgnet.com/1948-9366/full/v16/i5/1344.htm
DOI: https://dx.doi.org/10.4240/wjgs.v16.i5.1344