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©The Author(s) 2023.
World J Gastrointest Surg. Sep 27, 2023; 15(9): 1969-1977
Published online Sep 27, 2023. doi: 10.4240/wjgs.v15.i9.1969
Published online Sep 27, 2023. doi: 10.4240/wjgs.v15.i9.1969
Table 1 Basic characteristics between laparoscopic group and open group, n (%)
Variable | OMRA group, n = 41 | LMRA group, n = 68 | P value |
Age (yr) | |||
≤ 65 | 24 (58.5) | 31 (45.6) | 0.190 |
> 65 | 17 (41.5) | 37 (54.4) | |
Gender | |||
Female | 14 (34.1) | 26 (38.2) | 0.668 |
Male | 27 (65.9) | 42 (61.8) | |
ASA physical status | 0.058 | ||
I-II | 33 (80.5) | 63 (92.6) | |
III | 8 (19.5) | 5 (7.4) | |
Concomitant diseases | |||
No | 19 (46.3) | 29 (42.6) | 0.707 |
Yes | 22 (53.7) | 39 (57.4) | |
History of abdominal surgery | |||
No | 30 (73.2) | 56 (82.4) | 0.255 |
Yes | 11 (26.8) | 12 (17.6) | |
Preoperative chemotherapy | |||
No | 39 (95.1) | 68 (100) | 0.139 |
Yes | 2 (4.9) | 0 (0) | |
Tumor size1, cm | |||
≤ 5 | 20 (50.0) | 40 (58.8) | 0.373 |
> 5 | 20 (50.0) | 28 (41.2) | |
Tumor differentiation | |||
Well-moderate | 24 (58.5) | 32 (47.1) | 0.245 |
Poor | 17 (41.5) | 36 (52.9) | |
pT stage | |||
T1-T2 | 2 (4.9) | 7 (10.3) | 0.525 |
T3-T4 | 39 (95.1) | 61 (89.7) | |
pN stage | |||
N0 | 16 (39.0) | 25 (36.8) | 0.915 |
N1 | 19 (46.3) | 31 (45.6) | |
N2 | 6 (14.6) | 12 (17.6) | |
Stage | |||
I | 1 (2.4) | 6 (8.8) | 0.338 |
II | 15 (36.6) | 19 (27.9) | |
III | 25 (61.0) | 43 (63.2) | |
CEA | |||
≤ 5 | 19 (46.3) | 31 (45.6) | 0.929 |
> 5 | 13 (31.7) | 20 (29.4) | |
Unknown | 9 (22.0) | 17 (25.0) | |
CA199 | |||
≤ 37 | 28 (68.3) | 42 (61.8) | 0.696 |
> 37 | 3 (7.3) | 9 (13.2) | |
Unknown | 10 (24.4) | 17 (25.0) | |
Postoperative chemotherapy | |||
No | 20 (48.8) | 30 (44.1) | 0.636 |
Yes | 21 (51.2) | 38 (55.9) |
Table 2 Surgical results between laparoscopic group and open group
Variable | OMRA group, n = 41 | LMRA group, n = 68 | P value |
Operative time (min) | 253.0 ± 101.9 | 274.0 ± 83.4 | 0.244 |
Blood loss (mL) | 200 (30-600) | 100 (20-600) | 0.006 |
Time to first exhaust (d) | 3 (1-6) | 2 (1-4) | 0.001 |
Time to first liquid diets (d) | 4 (2-9) | 3 (2-6) | 0.012 |
Postoperative complications (Grade Ⅱ-V) | 7 (17.1) | 2 (2.9) | 0.025 |
Ileus | 2 (4.9) | 0 (0.0) | 0.139 |
Anastomotic leakage | 3 (7.3) | 2 (2.9) | 0.558 |
Cerebral infarction | 1 (2.4) | 0 (0.0) | 0.376 |
Abdominal incision infection | 1 (2.4) | 0 (0.0) | 0.376 |
No. of retrieved lymph nodes | 37.3 ± 17.1 | 45.2 ± 16.8 | 0.020 |
No. of positive lymph nodes | 1 (0-13) | 1 (0-15) | 0.542 |
Mortality | 0 (0) | 0 (0) | 1.000 |
Postoperative hospital stay, median, range, days | 12 (7-34) | 9 (3-30) | 0.002 |
Table 3 Univariate and multivariate analysis of overall survival and disease-free survival
Variable | Overall survival | Disease-free survival | ||||||
Univariable analysis | Multivariate analysis | Univariable analysis | Multivariate analysis | |||||
HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
Age (> 65/≤ 65 yr) | 2.830 (0.983-8.150) | 0.054 | 2.378 (0.793-7.128) | 0.122 | 2.048 (0.779-5.384) | 0.146 | 1.869 (0.674-5.188) | 0.230 |
Gender (male/female) | 1.051 (0.382-2.894) | 0.923 | 1.180 (0.436-3.191) | 0.744 | ||||
CEA level (> 5/≤ 5) | 1.278 (0.389-4.198) | 0.686 | 1.098 (0.348-3.465) | 0.873 | ||||
CA19-9 level (> 37/≤ 37) | 1.951 (0.506-7.521) | 0.332 | 1.304 (0.285-5.958) | 0.732 | ||||
ASA physical status (III/I-II) | 2.565 (0.817-8.050) | 0.106 | 2.280 (0.655-7.940) | 0.195 | ||||
Tumor differentiation (poor/well- moderate) | 0.918 (0.340-2.478) | 0.866 | 1.119 (0.431-2.906) | 0.817 | ||||
Tumor size (> 5/≤ 5 cm) | 1.058 (0.383-2.920) | 0.913 | 0.863 (0.328-2.269) | 0.764 | ||||
T stage (T3-T4/T1-T2) | 0.994 (0.130-7.627) | 0.994 | 1.302 (0.172-9.854) | 0.798 | ||||
N stage (N1-N2/N0) | 11.266 (1.487-85.384) | 0.019 | 10.161 (1.327-77.790) | 0.026 | 13.414 (1.775-101.359) | 0.012 | 13.107 (1.719-99.925) | 0.013 |
Operative approach (LMRA/OMRA) | 1.240 (0.426-3.611) | 0.693 | 0.834 (0.274-2.534) | 0.749 | 1.233 (0.432-3.516) | 0.695 | 0.812 (0.269-2.454) | 0.712 |
- Citation: Quan JC, Zhou XJ, Mei SW, Liu JG, Qiu WL, Zhang JZ, Li B, Li YG, Wang XS, Chang H, Tang JQ. Short- and long-term results of open vs laparoscopic multisegmental resection and anastomosis for synchronous colorectal cancer located in separate segments. World J Gastrointest Surg 2023; 15(9): 1969-1977
- URL: https://www.wjgnet.com/1948-9366/full/v15/i9/1969.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v15.i9.1969