Quan JC, Zhou XJ, Mei SW, Liu JG, Qiu WL, Zhang JZ, Li B, Li YG, Wang XS, Chang H, Tang JQ. Short- and long-term results of open vs laparoscopic multisegmental resection and anastomosis for synchronous colorectal cancer located in separate segments. World J Gastrointest Surg 2023; 15(9): 1969-1977 [PMID: 37901737 DOI: 10.4240/wjgs.v15.i9.1969]
Corresponding Author of This Article
Jian-Qiang Tang, MD, Surgeon, Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. doc_tjq@hotmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Sep 27, 2023; 15(9): 1969-1977 Published online Sep 27, 2023. doi: 10.4240/wjgs.v15.i9.1969
Short- and long-term results of open vs laparoscopic multisegmental resection and anastomosis for synchronous colorectal cancer located in separate segments
Ji-Chuan Quan, Shi-Wen Mei, Wen-Long Qiu, Jin-Zhu Zhang, Bo Li, Yue-Gang Li, Xi-Shan Wang, Jian-Qiang Tang, Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Xin-Jun Zhou, Department of Colorectal Anorectal Surgery, Shengli Oilfield Central Hospital, Dongying 257000, Shandong Province, China
Jun-Guang Liu, Department of General Surgery, Peking University First Hospital, Beijing 100034, China
Hu Chang, Department of Hospital Administration Office, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Quan JC and Zhou XJ contributed equally to this work; Quan JC and Chang H wrote the manuscript; Tang JQ, Zhou XJ and Wang XS conceived and designed the study; Quan JC, Liu JG, Chang H, Mei SW and Zhou XJ collected the data; Zhang JZ, Qiu WL, Li B and Li YG analyzed the data; all authors made critical revisions for the manuscript and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Cancer Hospital, Chinese Academy of Medical Sciences.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Qiang Tang, MD, Surgeon, Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. doc_tjq@hotmail.com
Received: May 3, 2023 Peer-review started: May 3, 2023 First decision: June 13, 2023 Revised: June 29, 2023 Accepted: July 27, 2023 Article in press: July 27, 2023 Published online: September 27, 2023 Processing time: 142 Days and 10.4 Hours
ARTICLE HIGHLIGHTS
Research background
Limited studies have focused on the differences between laparoscopic multisegmental resection and anastomosis (LMRA) and open multisegmental resection and anastomosis (OMRA) for synchronous colorectal cancer (SCRC) involving separate segments. Therefore, more studies on the safety and efficacy of LMRA are needed.
Research motivation
To assess the efficacy and safety of LMRA in patients with SCRC involving separate segments.
Research objectives
The objectives of this study were to compare the short-term efficacy and long-term oncological consequences of OMRA as well as LMRA for SCRC located in separate segments.
Research methods
A retrospective two-institution investigation was performed in 109 patients who received right hemicolectomy together with anterior resection of the rectum or right hemicolectomy and sigmoid colectomy. The OMRA and LMRA groups included 41 and 68 patients, respectively. The clinicopathological characteristics and surgical results were compared between the groups, and the Cox proportional hazards model was used to conduct univariate and multivariate prognostic analyses.
Research results
LMRA patients showed significantly shorter postoperative first exhaust time, postoperative first fluid intake time, and postoperative hospital stay than OMRA patients. Intraoperative blood loss, and the incidence of total postoperative complications (Clavien-Dindo grade: ≥ II) were markedly less in the LMRA group. The mean number of lymph nodes dissected was significantly higher in the LMRA group. Prognostic analysis showed that N stage was the independent prognostic factor for overall survival and disease-free survival.
Research conclusions
On the basis of this study, we conclude that LMRA has some short-term advantages compared with OMRA, and is safe and feasible for patients with SCRC located in separate segments.
Research perspectives
Future multicenter prospective studies are needed to further confirm the advantages of LMRA.
