Laboratory scoring system to predict hepatic indocyanine green clearance ability during fluorescence imaging-guided laparoscopic hepatectomy

Table 1 Patient basic characteristics

Characteristics	Patients, n = 110
Sex, male, n (%)	79 (71.80%)
Age in yr	54.09 ± 11.80
Height in cm	165.47 ± 7.349
Weight in kg	64.21 ± 11.64
Poor liver ICG clearance ability, subjective evaluation	23 (20.90%)
FI-LB	18.87 ± 17.06
FI-G	54.84 ± 33.29
FI-T	68.56 ± 36.11
TLR	14.05 ± 62.72
Cirrhosis	43 (39.10%)
Diabetes	11 (10.20%)
Liver cirrhosis	43 (39.80%)
First abdominal surgery	66 (61.10%)
Postoperative pathology diagnosis
HCC	67 (60.90%)
ICC	7 (6.40%)
Hepatic metastases	15 (13.60%)
Hepatic hemangioma	7 (6.40%)
FNH	3 (2.70%)
Tuberculosis lesions, etc.	11 (10.00%)

FI-G: Fluorescence intensity of gallbladder; FI-LB: Fluorescence intensity of liver background; FI-T: Fluorescence intensity of target area; FNH: Focal nodular hyperplasia; HCC: Hepatocellular carcinoma; ICG: Indocyanine green; ICC: Intrahepatic cholangiocarcinoma; TLR: Total laboratory risk.

Table 2 Univariate analysis of fluorescence intensity of liver background, fluorescence intensity of target area, fluorescence intensity of gallbladder, total laboratory risk and preoperative blood indicators (Spearman correlation analysis)

Factor	FI-LB		FI-T		FI-G		TLR
	Correlation coefficient	P value	Correlation coefficient	P value	Correlation coefficient	P value	Correlation coefficient	P value
APRI-Score	0.136	0.160	0.005	0.957	0.016	0.878	-0.148	0.135
RBC	-0.234a	0.014	-0.099	0.313	-0.273b	0.008	0.113	0.250
Hb	-0.154	0.109	-0.093	0.344	-0.247a	0.016	0.035	0.721
Plt	-0.038	0.695	0.063	0.521	-0.139	0.182	0.054	0.583
TP	-0.050	0.605	0.049	0.620	-0.001	0.992	0.019	0.843
ALB	-0.084	0.384	0.016	0.870	-0.158	0.129	0.001	0.989
TBil	-0.026	0.791	-0.192a	0.048	0.052	0.621	-0.037	0.705
DBil	0.078	0.438	-0.105	0.302	0.052	0.635	-0.071	0.489
TA	-0.058	0.558	-0.049	0.629	0.045	0.677	0.045	0.657
AST	0.191a	0.048	0.074	0.454	-0.066	0.530	-0.168	0.088
ALT	0.253b	0.009	0.093	0.349	0.114	0.282	-0.191	0.053
GGT	0.197a	0.044	0.231a	0.020	0.133	0.211	-0.003	0.978
ALP	0.050	0.612	0.057	0.574	-0.106	0.321	-0.031	0.758
CHE	-0.224a	0.020	-0.144	0.144	-0.225a	0.031	0.053	0.591
LDH	0.233a	0.017	0.269b	0.007	0.105	0.331	-0.045	0.656
ADA	0.200a	0.045	0.053	0.604	0.216a	0.046	-0.112	0.275
INR	-0.072	0.457	-0.106	0.280	-0.043	0.684	0.074	0.448
PTA	0.073	0.448	0.108	0.271	0.044	0.675	-0.072	0.465
PT	-0.030	0.756	-0.066	0.499	0.017	0.874	0.028	0.775
APTT	-0.168	0.080	-0.248a	0.010	0.030	0.773	-0.095	0.330
Fib	0.086	0.373	0.118	0.227	0.038	0.713	-0.064	0.516
TT	0.109	0.256	0.008	0.936	0.014	0.892	-0.055	0.574

^aP < 0.05;

^bP < 0.005.

ADA: Adenosine deaminase; ALB: Albumin; ALT: Alanine aminotransferase; APRI: Aspartate aminotransferase-to-platelet ratio index; APTT: Partially activated thromboplastin time; AST: Aspartate aminotransferase; CHE: Cholinesterase; DBil: Direct bilirubin; Fib: Fibrinogen; FI-G: Fluorescence intensity of gallbladder; FI-LB: Fluorescence intensity of liver background; FI-T: Fluorescence intensity of target area; GGT: Gamma-glutamyl transpeptidase; Hb: Hemoglobin; INR: International normalized ratio; LDH: Lactate dehydrogenase; Plt: Platelet count; PT: Prothrombin time; PTA: Prothrombin activity; RBC: Red blood cell; TA: Total bile acid; TBil: Total bilirubin; TP: Total protein; TT: Thrombin time.

Table 3 Laboratory blood indicators risk scores calculating rules

Variables’ relationship	Correlation coefficient	Cut-off group	Score
Positive correlation	0.1-0.2	High	1
Positive correlation	> 0.2	High	2
Negative correlation	0.1-0.2	Low	1
Negative correlation	> 0.2	Low	2