Choice of operative method for pancreaticojejunostomy and a multivariable study of pancreatic leakage in pancreaticoduodenectomy

Table 1 Comparison of general parameters between group A and group B

Group	Cases	Male/female	Age (yr)	Albumin(g/L)	Hemoglobin (g/L)	Disease types
						Carcinoma of the head of the pancreas	Carcinoma of the ampulla	Carcinoma of the lower common bile duct	Duodenal carcinoma
A group	198	110/88	60.33 ± 9.82	36.70 ± 4.40	110.02 ± 10.43	93 (46.97)	52 (26.26)	31 (15.66)	22 (11.11)
B group	222	132/90	59.81 ± 10.11	36.12 ± 5.53	109.82 ± 12.21	108 (48.65)	72 (32.43)	29 (13.06)	13 (5.86)
t/χ2		0.653	0.533	1.180	0.179	5.372
P value		0.419	0.594	0.239	0.858	0.146

Table 2 Comparison of operation time and anastomosis time between group A and group B

Group	Cases	Operation time (h)	Intraoperative blood loss (mL)	Pancreaticojejunostomy time (min)	Diameter of pancreatic duct (mm)
A group	198	5.02 ± 0.82	430.40 ± 50.03	26.03 ± 4.40	3.90 ± 1.10
B group	222	4.97 ± 0.90	429.28 ± 47.74	21.19 ± 3.77	2.50 ± 0.88
t		0.593	0.235	12.139	14.470
P value		0.554	0.815	0.000	0.000

Table 3 Comparison of pancreatic leakage and other complications between group A and group B, n (%)

Group	Cases	Pancreatic leakage	Abdominal infection	Abdominal hemorrhage	Gastric retention
A group	198	14 (7.07)	8 (4.04)	7 (3.54)	7 (3.54)
B group	222	21 (9.46)	10 (4.50)	9 (4.05)	8 (3.60)
χ2		0.782	0.055	0.077	0.001
P value		0.377	0.815	0.782	0.970

Table 4 Relationship between postoperative pancreatic leakage and clinical indicators, n (%)

Index	Cases	Postoperative pancreatic leakage	χ2	P value
Age (yr)			0.072	0.789
≤ 60	243	21 (8.64)
> 60	177	14 (7.91)
Sex			0.004	0.953
Male	242	20 (8.26)
Female	178	15 (8.43)
Diabetes			0.153	0.696
Yes	120	11 (9.17)
No	300	24 (8.00)
Hypertension			0.089	0.766
Yes	178	14 (7.87)
No	242	21 (8.68)
Preoperative albumin			33.739	0.000
< 30 g/L	90	21 (23.33)
≥ 30 g/L	330	14 (4.24)
Preoperative jaundice time			52.154	0.000
< 8 wk	367	17 (4.63)
≥ 8 wk	53	18 (33.96)
Operation time			0.022	0.883
< 4 h	209	17 (8.13)
≥ 4 h	211	18 (8.53)
Intraoperative blood loss			0.087	0.768
< 430 mL	230	20 (8.70)
≥ 430 mL	190	15 (7.89)
Vascular resection and reconstruction			0.000	1.000
Yes	60	5 (8.33)
No	360	30 (8.33)
Pancreatic texture			0.022	0.883
Soft	221	18 (8.14)
Hard	199	17 (8.54)
Diameter of pancreatic duct			25.355	0.000
< 3 mm	121	23 (19.01)
≥ 3 mm	299	12 (4.01)
Pancreaticojejunostomy time			0.305	0.580
< 30 min	320	28 (8.75)
≥ 30 min	100	7 (7.00)
Pancreatic duct indwelling support tube			0.162	0.687
Yes	335	27 (8.06)
No	85	8 (9.41)
Disease types			0.018	0.999
Carcinoma of the head of the pancreas	201	17 (8.46)
Carcinoma of the ampulla	124	10 (8.06)
Carcinoma of the lower common bile duct	60	5 (8.33)
Duodenal carcinoma	35	3 (8.57)

Table 5 Multivariate analysis

Factor	β	SE	Walds	P value	Odds ratio (95%CI)
Preoperative albumin < 30 g/L	0.712	0.202	12.424	0.000	2.038 (1.372-3.028)
Preoperative jaundice time ≥ 8 wk	0.882	0.329	7.187	0.000	2.416 (1.268-4.604)
Diameter of pancreatic duct < 3 mm	0.982	0.311	9.970	0.000	2.670 (1.451-4.911)