Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy

Figure 1 Comparison of plasma interleukin-6, interleukin-8, and C-reactive protein between the no clinically relevant postoperative pancreatic fistula and clinically relevant postoperative pancreatic fistula groups. CR-POPF: Clinically relevant postoperative pancreatic fistula; CRP: C-reactive protein; IL: Interleukin; POD: Postoperative day.

Figure 2 Diagnostic accuracy of biomarkers for clinically relevant postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy. A: Postoperative day (POD) 1; B: POD3. Regarding the diagnostic accuracy for clinically relevant postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy on POD1 and POD3, several biomarkers demonstrated varying effectiveness. CRP: C-reactive protein; DAC: Drain fluid amylase concentration; DSACR: Drain-to-serum amylase concentration ratio; IL: Interleukin; POD: Postoperative day; SAC: Serum amylase concentration.

Figure 3 The combined diagnostic efficacy of plasma levels of C-reactive protein, interleukin-8, and interleukin-6, in addition to drain fluid amylase concentration, serum amylase concentration, and drain-to-serum amylase concentration ratio, was evaluated for predicting clinically relevant postoperative pancreatic fistula post laparoscopic pancreaticoduodenectomy on both the postoperative day 1 and postoperative day 3 postoperative days. POD: Postoperative day.