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World J Gastrointest Surg. Jun 27, 2026; 18(6): 115706
Published online Jun 27, 2026. doi: 10.4240/wjgs.115706
Published online Jun 27, 2026. doi: 10.4240/wjgs.115706
Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy
Jian-Kang Yang, Ya-Qi Gu, Zong-Guo He, Department of Hepatopancreatobiliary Surgery, Huainan Xinhua Hospital Affiliated to Anhui University of Science and Technology, Huainan 232000, Anhui Province, China
Fu-Bao Liu, Department of Hepatobiliary and Pancreas Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 235211, Anhui Province, China
Author contributions: Yang JK, Gu YQ and He ZG contributed to conceiving the research and analyzing data; Yang JK and Liu FB designed the research and wrote the first manuscript, conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study is a retrospective analysis, the data has been de-identified, and it was collected retrospectively, therefore no institutional review board certification is required.
Informed consent statement: The requirement for written informed consent was waived due to retrospective design of the study.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Data sharing statement: No additional data are available.
Corresponding author: Fu-Bao Liu, Chief Physician, Department of Hepatobiliary and Pancreas Surgery, The First Affiliated Hospital of Anhui Medical University, Jiankang Road, Xiejiaji District, Hefei 235211, Anhui Province, China. 18155415185@163.com
Received: December 16, 2025
Revised: January 12, 2026
Accepted: March 27, 2026
Published online: June 27, 2026
Processing time: 183 Days and 5.8 Hours
Revised: January 12, 2026
Accepted: March 27, 2026
Published online: June 27, 2026
Processing time: 183 Days and 5.8 Hours
Core Tip
Core Tip: Clinically relevant postoperative pancreatic fistula remains a major driver of morbidity after laparoscopic pancreaticoduodenectomy. A combined model incorporating amylase indices (drain fluid amylase concentration, serum amylase concentration, drain-to-serum amylase concentration ratio) and inflammatory markers (interleukin-6/interleukin-8/C-reactive protein) showed high areas under the receiver operating characteristic curves on postoperative day 1 and postoperative day 3, supporting early identification of high-risk patients.