Correlation between inflammatory markers and disease severity in ulcerative colitis

Figure 1 Association between ulcerative colitis severity and systemic inflammatory markers. ^aP < 0.01; ^bP < 0.001. A: Interleukin-6 concentrations across severity groups; B: Tumor necrosis factor-alpha concentrations across severity groups; C: C-reactive protein concentrations across severity groups. IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; CRP: C-reactive protein.

Figure 2 Correlation matrices of inflammatory markers with ulcerative colitis severity. A: Interleukin-6 vs Mayo score; B: Tumor necrosis factor-alpha vs Mayo score; C: C-reactive protein vs Mayo score. IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; CRP: C-reactive protein.

Figure 3 Odds ratio distributions from Bootstrap sensitivity testing (n = 1000 iterations). A: Odds ratio (OR) distribution for smoking history sensitivity analysis; B: Alcohol abuse history OR distribution analysis; C: Interleukin-6-related OR stability across resamples; D: Tumor necrosis factor-alpha-associated OR consistency analysis; E: C-reactive protein-based OR robustness evaluation. OR: Odds ratio; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; CRP: C-reactive protein.

Figure 4 Receiver operating characteristic curve of the multi-factor combined prediction model. IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; CRP: C-reactive protein.