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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2025; 17(12): 108880
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.108880
Published online Dec 27, 2025. doi: 10.4240/wjgs.v17.i12.108880
Correlation between inflammatory markers and disease severity in ulcerative colitis
Jie Fu, College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China
Yue-Yu Zhang, Department of Rehabilitation, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China
Yue-Yu Zhang, College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China
Author contributions: Fu J was responsible for writing, data analysis, and visualization; Zhang YY took charge of conceptualization; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the 2019 TCM Evidence-based Practice Capacity Building Project of the State Administration of Traditional Chinese Medicine, No. 2019XZZX-ZJ006; and the 2020 “Special Project on Traditional Chinese Medicine Ancient Books and Characteristic Technology Inheritance”, No. 295.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Central Hospital of Wuhan.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Fu, MD, College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, No. 188 Tanhualin, Wuhan 430065, Hubei Province, China.
Received: July 11, 2025
Revised: August 18, 2025
Accepted: October 21, 2025
Published online: December 27, 2025
Processing time: 166 Days and 17.4 Hours
Revised: August 18, 2025
Accepted: October 21, 2025
Published online: December 27, 2025
Processing time: 166 Days and 17.4 Hours
Core Tip
Core Tip: The study evaluated whether interleukin-6, tumor necrosis factor-α, and C-reactive protein levels correlate with the severity of ulcerative colitis (UC). Analyses confirm strong positive relationships, supporting their utility as noninvasive biomarkers for UC progression. Of note, the interleukin-6 + tumor necrosis factor-α + C-reactive protein combination outperformed single-marker testing in identifying severe UC cases.