Regional differences in islet amyloid deposition in the residual pancreas with new-onset diabetes secondary to pancreatic ductal adenocarcinoma

Figure 1 Preoperative magnetic resonance imaging image and histopathologic image of the surgical resection of pancreatic specimens of pancreatic ductal adenocarcinoma patients with new-onset diabetes. A and B: Magnetic resonance imaging images (A) and images of surgical specimens (B) from pancreatic ductal adenocarcinoma patients showed pancreatic head tumor invading the main pancreatic duct, leading to dilation of the pancreatic duct and atrophy of the body and tail of the pancreas; C and D: Representative images of hematoxylin and eosin staining from the proximal (C) or distal (D) pancreas.

Figure 2 Islet immunohistochemical and immunofluorescent analysis of the proximal/distal pancreas of pancreatic ductal adenocarcinoma patients with new-onset diabetes. A and B: Representative images of immunohistochemical staining for insulin from the proximal (A) or distal (B) pancreas; C and D: Representative quadruple insulin (red), glucagon (green), thioflavin T (white) and DAPI (blue) staining from the proximal (C) or distal (D) pancreas for the determination of β-cell area, α-cell area and amyloid deposits.