Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Aug 27, 2023; 15(8): 1703-1711
Published online Aug 27, 2023. doi: 10.4240/wjgs.v15.i8.1703
Regional differences in islet amyloid deposition in the residual pancreas with new-onset diabetes secondary to pancreatic ductal adenocarcinoma
Rui Wang, Ya Liu, Yan Liang, Li Zhou, Mao-Jia Chen, Xu-Bao Liu, Chun-Lu Tan, Yong-Hua Chen
Rui Wang, Xu-Bao Liu, Chun-Lu Tan, Yong-Hua Chen, Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Ya Liu, Department of General Surgery, Chengdu Second People's Hospital, Chengdu 610041, Sichuan Province, China
Yan Liang, Li Zhou, Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Mao-Jia Chen, Animal Experimental Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Chen YH and Tan CL contributed equally to this work; Chen YH, Tan CL and Liu XB conceived and designed the research; Wang R, Liu Y, Liang Y, Zhou L and Chen MJ collected the data and conducted the research; Wang R, Liu Y, Liang Y, Zhou L and Chen MJ analysed and interpreted the data; Wang R and Liu Y wrote the initial paper; Chen YH and Tan CL revised the paper; all authors contributed to the article and approved the submitted version.
Supported by the Key Research and Development Projects in Sichuan Province, No. 2019YFS0043; and 1·3·5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, No. ZY2017302-1.3.5.
Institutional review board statement: The study was approved by the Biomedical Research Ethics Committee of West China Hospital, Sichuan University (2014No.37).
Informed consent statement: All study participants or their legal guardians provided informed written consent about personal and medical data collection prior to study enrollment.
Conflict-of-interest statement: All authors report no relevant conflict of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Hua Chen, MD, PhD, Associate Professor, Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. chenyonghua2007@163.com
Received: April 5, 2023
Peer-review started: April 5, 2023
First decision: May 12, 2023
Revised: May 16, 2023
Accepted: June 6, 2023
Article in press: June 6, 2023
Published online: August 27, 2023
Processing time: 142 Days and 4 Hours
Core Tip

Core Tip: This retrospective study investigated the relationship between islet amyloid deposition of the residual pancreas in 45 pancreatic ductal adenocarcinoma (PDAC) patients with different glycemic status and to explore whether regional differences (proximal vs. distal residual pancreas) are associated with islet amyloid deposition. Our findings suggest that robust alterations of the distal pancreas due to tumors can disturb islet function and structure with islet amyloid formation, which may be associated with the pathogenesis of new-onset diabetes secondary to PDAC.