Effects of cytoreductive surgery combined with hyperthermic perfusion chemotherapy on prognosis of patients with advanced gallbladder cancer

Figure 1 Liver function indices before and after surgery. A: Alanine aminotransferase; B: Aspartate aminotransferase; C: Total bilirubin; D: Direct bilirubin concentrations before (orange) and after (green) surgery. ^aP < 0.05; ^bP < 0.01; ^dP < 0.0001. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; DBIL: Direct bilirubin.

Figure 2 Renal function markers before and after surgery. A: Creatinine; B: Blood urea nitrogen concentrations before (orange) and after (green) surgery. ^cP < 0.001, ^dP < 0.0001. Cr: Creatinine; BUN: Blood urea nitrogen.

Figure 3 Three-year survival curves of independent prognostic factors. A: Overall survival; B: Tumor stage; C: Distant metastasis; D: Treatment plan. HIPEC: Hyperthermic intraperitoneal chemotherapy.