Prognostic value of acute liver injury in cirrhotic patients after the transjugular intrahepatic portosystemic shunt procedure

doi:10.4240/wjgs.121016

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Aug 27, 2026; 18(8): 121016
Published online Aug 27, 2026. doi: 10.4240/wjgs.121016

Prognostic value of acute liver injury in cirrhotic patients after the transjugular intrahepatic portosystemic shunt procedure

Liang Yin, Jing-Qiu Zhang, Yi-Jiang Zhu, Sen-Lin Chu, Kai-Cai Liu, Pan Zhang, Li Dong, Yong-Hui Zhang, Dong Lu, Wei-Fu Lv, Chun-Ze Zhou, De-Lei Cheng

Liang Yin, Jing-Qiu Zhang, Yi-Jiang Zhu, Sen-Lin Chu, Pan Zhang, Li Dong, Yong-Hui Zhang, Wei-Fu Lv, Chun-Ze Zhou, De-Lei Cheng, Department of Interventional Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230000, Anhui Province, China

Kai-Cai Liu, Department of Interventional Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China

Dong Lu, Department of Interventional Radiology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China

Co-first authors: Liang Yin and Jing-Qiu Zhang.

Co-corresponding authors: Chun-Ze Zhou and De-Lei Cheng.

Author contributions: Yin L and Zhang JQ wrote the manuscript, designed figures and tables and they contributed equally to this article as co-first authors; Zhu YJ, Chu SL, Liu KC, Zhang P, Dong L, Zhang YH and Lu D performed the research and collected the data; Lv WF, Zhou CZ and Cheng DL analyzed the data and provided technical support; Zhou CZ and Cheng DL oversaw supervision and project administration and they contributed equally to this article as co-corresponding authors; and all authors have read and approved the final manuscript.

Supported by 2023 Health Research Program of Anhui, No. AHWJ2023A20508; and 2023 Hefei Natural Science Foundation, No. 202341.

Institutional review board statement: This study was approved by the Institutional Review Board of the First Affiliated Hospital of the University of Science and Technology of China and complied with the Declaration of Helsinki (Approval No. 2023-RE-157).

Informed consent statement: Given the study’s retrospective design, the need for informed consent was waived by the Institutional Review Board of the First Affiliated Hospital of the University of Science and Technology of China.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: The corresponding author will provide the datasets generated during this study upon reasonable request to the editor, in accordance with institutional data sharing policies.

Corresponding author: De-Lei Cheng, PhD, Department of Interventional Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230000, Anhui Province, China. chengdelei@hotmail.com

Received: March 13, 2026
Revised: April 28, 2026
Accepted: May 18, 2026
Published online: August 27, 2026
Processing time: 157 Days and 9.6 Hours

Core Tip

Core Tip: Acute liver injury (ALI) is a common and serious complication following the transjugular intrahepatic portosystemic shunt (TIPS) procedure in cirrhotic patients. This study highlights the incidence, risk factors, and prognostic implications of ALI after TIPS. Our findings demonstrate that post-TIPS ALI significantly increases the risk of overt hepatic encephalopathy and reduces overall survival. Independent predictors of mortality include sarcopenia, Model for End-Stage Liver Disease score, age, and post-TIPS ALI. A nomogram was developed based on these key factors, offering a reliable tool for survival prediction and clinical decision-making in managing cirrhotic patients undergoing TIPS.