Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Aug 27, 2026; 18(8): 120491
Published online Aug 27, 2026. doi: 10.4240/wjgs.120491
Published online Aug 27, 2026. doi: 10.4240/wjgs.120491
Oxycodone-dexmedetomidine vs fentanyl analgesia in septic patients after gastric perforation surgery
Lian-Chao Men, Department of Emergency Medicine, Hejian Branch of Cangzhou Central Hospital, Cangzhou 062450, Hebei Province, China
Li-Zeng Wang, Ying Zhang, Yu Han, Department of Critical Care Medicine, Hejian Branch of Cangzhou Central Hospital, Cangzhou 062450, Hebei Province, China
Cong-Ying Ma, Department of Emergency, Hejian Branch of Cangzhou Central Hospital, Cangzhou 062450, Hebei Province, China
Author contributions: Men LC and Wang LZ contributed to study design, data collection, and statistical analysis; Ma CY participated in patient recruitment and clinical data management; Zhang Y assisted with data analysis and literature review; Han Y supervised the study and critically revised the manuscript. All authors contributed to manuscript preparation, reviewed the final version, and approved it for publication.
AI contribution statement: AI was used solely to polish the language in the preface. All other sections were written entirely without AI assistance.
Supported by Bethune Public Welfare Foundation-Enze Pain Management Medical Research Project, No. ezmr2024-039.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Cangzhou Central Hospital, Hejian Branch, No. 2025-1091-01 (z).
Informed consent statement: The requirement for informed consent was waived by the Ethics Committee of Cangzhou Central Hospital, Hejian Branch, because this was a retrospective study based on anonymized clinical data and involved no additional risk to patients.
Conflict-of-interest statement: All authors declare that they have no conflict of interest related to this study.
Data sharing statement: De-identified participant data are available from the corresponding author upon reasonable request.
Corresponding author: Yu Han, Department of Critical Care Medicine, Hejian Branch of Cangzhou Central Hospital, No. 32 Jingkai South Street, Cangzhou 062450, Hebei Province, China. hangyudr@163.com
Received: February 27, 2026
Revised: March 31, 2026
Accepted: July 15, 2026
Published online: August 27, 2026
Processing time: 170 Days and 14.4 Hours
Revised: March 31, 2026
Accepted: July 15, 2026
Published online: August 27, 2026
Processing time: 170 Days and 14.4 Hours
Core Tip
Core Tip: Sepsis following gastric perforation surgery is associated with high morbidity and prolonged intensive care unit (ICU) stay. Optimizing postoperative analgesia and sedation may influence inflammatory response and organ recovery in these patients. This retrospective cohort study demonstrates that oxycodone combined with dexmedetomidine provides superior analgesia and sedation compared with conventional fentanyl, with improved inflammatory control, enhanced hemodynamic stability, shorter ICU stay, reduced mechanical ventilation duration, and a lower incidence of delirium. These findings support the clinical value of dexmedetomidine-based multimodal analgesia strategies in septic patients after gastric perforation surgery.