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World J Gastrointest Surg. Aug 27, 2026; 18(8): 118864
Published online Aug 27, 2026. doi: 10.4240/wjgs.118864
Published online Aug 27, 2026. doi: 10.4240/wjgs.118864
Efficacy of thrombin spray combined with clip closure after colorectal endoscopic mucosal resection and endoscopic submucosal dissection
Shi-Song Gu, Peng Zhang, Ke-Dong Zhu, Department of Gastroenterology, The Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou), Chuzhou 239000, Anhui Province, China
Author contributions: Gu SS collected and analyzed the data, and drafted the manuscript; Zhang P recruited patients, performed perioperative management, and acquired clinical data; Zhu KD conceptualized and designed the study, supervised all endoscopic procedures, critically revised the manuscript, and approved the final version for submission; and all authors read and approved the final manuscript.
Supported by the Chuzhou Health Research Project, No. CZWJ2024C001.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou), approval No. 2025-IRB-BIO-82.
Clinical trial registration statement: Not applicable. This study was a retrospective clinical study and was not registered as a clinical trial.
Informed consent statement: The informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: De-identified participant data are available from the corresponding author on reasonable request.
Corresponding author: Ke-Dong Zhu, MD, Department of Gastroenterology, The Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou), No. 369 Zui weng West Road, Nanqiao District, Chuzhou 239000, Anhui Province, China.
Received: February 6, 2026
Revised: March 19, 2026
Accepted: May 19, 2026
Published online: August 27, 2026
Processing time: 191 Days and 1.1 Hours
Revised: March 19, 2026
Accepted: May 19, 2026
Published online: August 27, 2026
Processing time: 191 Days and 1.1 Hours
Core Tip
Core Tip: This study demonstrates that combining endoscopic thrombin powder spraying with titanium clip mechanical closure provides synergistic hemostasis for colorectal endoscopic mucosal resection and endoscopic submucosal dissection wounds. This dual strategy not only improves intraoperative bleeding control but also reduces postoperative pain, accelerates functional recovery, and enhances early postoperative quality of life without increasing complication risk. The findings suggest that chemical-mechanical hybrid wound management may represent a safer and more effective modality for preventing bleeding after advanced colorectal endoscopic resection.