Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Aug 27, 2026; 18(8): 116300
Published online Aug 27, 2026. doi: 10.4240/wjgs.116300
Published online Aug 27, 2026. doi: 10.4240/wjgs.116300
Acute pancreatitis, hypercalcemia, and kidney stones: True incidence or unveiled prevalence?
Selcuk Yuksel, Department of Internal Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale 17020, Türkiye
Selcuk Yuksel, Chair of the Department of Internal Medical Sciences, Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale 17020, Türkiye
Author contributions: Yuksel S conceptualized the opinion review; performed the literature review and critical appraisal; drafted, revised, and approved the final manuscript.
AI contribution statement: AI-assisted writing and language support tools were used during manuscript preparation. AI tools were used for writing assistance and language support. They were not used as an independent source of scientific judgment. The author takes full responsibility for the scientific content, interpretation, wording, and final form of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Selcuk Yuksel, Professor, Department of Internal Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale 17020, Türkiye.
Received: November 13, 2025
Revised: December 10, 2025
Accepted: January 15, 2026
Published online: August 27, 2026
Processing time: 276 Days and 11.1 Hours
Revised: December 10, 2025
Accepted: January 15, 2026
Published online: August 27, 2026
Processing time: 276 Days and 11.1 Hours
Core Tip
Core Tip: The association between hypercalcemia and renal stone detection in acute pancreatitis is clinically important, but a 7-day timeline is biologically inconsistent with established lithogenesis. Serial ultrasonography during acute illness is more likely to reveal pre-existing silent microlithiasis or transient crystal aggregates than true de novo nephrolithiasis. Distinguishing unveiled prevalence from true incidence is essential because it changes both the interpretation of the study and subsequent patient management.