Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Jul 27, 2026; 18(7): 121498
Published online Jul 27, 2026. doi: 10.4240/wjgs.v18.i7.121498
Published online Jul 27, 2026. doi: 10.4240/wjgs.v18.i7.121498
Clinical characteristics of hospitalized children with gastrointestinal bleeding and risk factors for associated anemia
Yun Yao, Yan Hu, Yi Chen, Yu-Ping Wang, Chuan-Ying Li, Department of Pediatric Gastro
Author contributions: Yao Y was responsible for data curation, analysis, as well as manuscript drafting, editing, and review; Wang YP and Chen Y undertook data curation, validation, and formal statistical analysis; Hu Y provided resources and support for the research; Li CY supervised the study and managed the project; all authors jointly agreed to submit the manuscript to this journal, confirmed that the submitted version is the final version, and committed to being responsible for the entire process and the research work content.
Institutional review board statement: This study complies with the Declaration of Helsinki and has been approved by the Ethics Committee of Anhui Provincial Children’s Hospital (Approval No. 2026-19).
Informed consent statement: All study participants or their legal guardians provided written informed consent prior to enrollment in this study.
Conflict-of-interest statement: No conflicts of interest for this article.
Data sharing statement: All experimental data included in this study can be obtained by contacting the corresponding author if needed.
Corresponding author: Chuan-Ying Li, Academic Fellow, Department of Pediatric Gas
Received: April 2, 2026
Revised: April 28, 2026
Accepted: May 9, 2026
Published online: July 27, 2026
Processing time: 119 Days and 0.1 Hours
Revised: April 28, 2026
Accepted: May 9, 2026
Published online: July 27, 2026
Processing time: 119 Days and 0.1 Hours
Core Tip
Core Tip: This single-center retrospective study of 257 hospitalized children found an anemia incidence of 17.5%. Key independent risk factors for anemia included melena, low albumin levels, low lymphocyte count, and shortened activated partial thromboplastin time (APTT). Diarrhea was identified as a protective factor. Notably, shortened APTT, rather than prolonged APTT, emerged as a novel independent risk factor, suggesting a possible compensatory coagulation response to chronic bleeding. These findings highlight the necessity of early identification of high-risk children to enable timely intervention.