Li KN, Chen Q, Huang CT, Liu TQ, Li HF. Long-term survival after pancreaticoduodenectomy for duodenal papillary adenocarcinoma in a patient with acquired immunodeficiency syndrome: A case report and review of literature. World J Gastrointest Surg 2026; 18(7): 117966 [DOI: 10.4240/wjgs.117966]
Corresponding Author of This Article
Tian-Qi Liu, MD, PhD, Chief Physician, Department of General Surgery, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, No. 85 Heti Road, Qingxiu District, Nanning 530021, Guangxi Zhuang Autonomous Region, China. gxljrqt@163.com
Research Domain of This Article
Gastroenterology & Hepatology
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case-report
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Li KN, Chen Q, Huang CT, Liu TQ, Li HF. Long-term survival after pancreaticoduodenectomy for duodenal papillary adenocarcinoma in a patient with acquired immunodeficiency syndrome: A case report and review of literature. World J Gastrointest Surg 2026; 18(7): 117966 [DOI: 10.4240/wjgs.117966]
World J Gastrointest Surg. Jul 27, 2026; 18(7): 117966 Published online Jul 27, 2026. doi: 10.4240/wjgs.117966
Long-term survival after pancreaticoduodenectomy for duodenal papillary adenocarcinoma in a patient with acquired immunodeficiency syndrome: A case report and review of literature
Kang-Ning Li, Qing Chen, Chun-Tao Huang, Tian-Qi Liu, Hong-Fei Li
Kang-Ning Li, Chun-Tao Huang, Graduate School, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Qing Chen, Department of Scientific Research and Education, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Tian-Qi Liu, Department of General Surgery, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Hong-Fei Li, Department of Hepatobiliary Surgery, Hechi Hospital Affiliated to Youjiang Medical University for Nationalities, Hechi 547000, Guangxi Zhuang Autonomous Region, China
Co-first authors: Kang-Ning Li and Qing Chen.
Co-corresponding authors: Tian-Qi Liu and Hong-Fei Li.
Author contributions: Li KN, Chen Q, and Huang CT drafted the initial manuscript; Li KN and Chen Q made equal contributions as co-first authors; Liu TQ and Li HF diagnosed and treated the patient, and reviewed and edited the manuscript as co-corresponding authors. All authors take responsibility for the final submitted version and have read and approved the final manuscript.
AI contribution statement: No generative AI was used to create any clinical or academic content. Only AI tools were employed within a limited auxiliary scope. DeepL was used to perform the initial translation of the original Chinese manuscript (written independently by us) into English during the process. DeepSeek was only used for its text proofreading function to check for basic spelling and grammar errors in the translation draft. All the content of this paper, including the complete case presentation, clinical details, and academic discussions, was independently conceived, written, and revised by the authors.
Supported by Medical and Health Appropriate Technology Development and Promotion Project of the Health Commission of Guangxi Zhuang Autonomous Region, No. S2023034.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Tian-Qi Liu, MD, PhD, Chief Physician, Department of General Surgery, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, No. 85 Heti Road, Qingxiu District, Nanning 530021, Guangxi Zhuang Autonomous Region, China. gxljrqt@163.com
Received: December 22, 2025 Revised: March 12, 2026 Accepted: April 17, 2026 Published online: July 27, 2026 Processing time: 219 Days and 2 Hours
Core Tip
Core Tip: This case demonstrates that pancreaticoduodenectomy can achieve 5-year disease-free survival in patients with duodenal papillary adenocarcinoma complicated by acquired immunodeficiency syndrome, and represents the first case with comprehensive long-term prognostic outcomes documented for this specific patient population. Key factors for treatment success include effective multidisciplinary team collaborative management, tailored chemotherapy regimens guided by the patient’s absolute neutrophil count, and proactive perioperative infection prophylaxis. This case suggests that surgical eligibility should not simply be based on a CD4+ T-cell count ≥ 200 cells/μL as the absolute criterion; instead, it should be determined through comprehensive assessment incorporating the CD4+ count, viral load control, nutritional status, and tumor-specific factors.
