Effect of propofol and remimazolam on post-induction hypotension in hypertensive patients undergoing laparoscopic cholecystectomy

doi:10.4240/wjgs.120158

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Jun 27, 2026; 18(6): 120158
Published online Jun 27, 2026. doi: 10.4240/wjgs.120158

Effect of propofol and remimazolam on post-induction hypotension in hypertensive patients undergoing laparoscopic cholecystectomy

Yu-Ting Zhang, Shuan-Cheng Bai

Yu-Ting Zhang, Affiliated Baotou Clinical College of Inner Mongolia Medical University, Baotou 014040, Inner Mongolia Autonomous Region, China

Shuan-Cheng Bai, Department of Anesthesiology, Affiliated Baotou Clinical College of Inner Mongolia Medical University, Baotou 014040, Inner Mongolia Autonomous Region, China

Author contributions: Zhang YT and Bai SC conceived and designed the study; Zhang YT conducted the methodology and investigation and prepared the original draft of the manuscript; Bai SC contributed to the review and editing of the manuscript; Zhang YT was responsible for visualization, while Bai SC provided supervision; all authors have read and approved the final version of the manuscript.

Supported by the Zhongguancun Precision Medicine Foundation Project, No. 2024-1--097.

Institutional review board statement: Ethical approval for this study [Approval No. KYLL2024 (Ethics) 081] was obtained from the Ethics Committee of the Baotou Central Hospital.

Clinical trial registration statement: The trial was registered with the Clinical Trial Registry of China (ChiCTR2600117697).

Informed consent statement: All participants provided written informed consent.

Conflict-of-interest statement: The authors declare no competing interests.

CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.

Data sharing statement: All patient data can be requested by sending an email to the corresponding author.

Corresponding author: Shuan-Cheng Bai, Department of Anesthesiology, Affiliated Baotou Clinical College of Inner Mongolia Medical University, No. 61 Huancheng Road, Donghe District, Baotou 014040, Inner Mongolia Autonomous Region, China. bsc0130@163.com

Received: February 24, 2026
Revised: March 5, 2026
Accepted: April 8, 2026
Published online: June 27, 2026
Processing time: 125 Days and 5.9 Hours

Core Tip

Core Tip: This study compared the incidence of post-induction hypotension (PIH) and hemodynamic stability between remimazolam and propofol during total intravenous anesthesia in hypertensive patients undergoing laparoscopic cholecystectomy. Compared to propofol, remimazolam significantly reduced the incidence and duration of PIH and decreased the use of norepinephrine. Remimazolam also had a lower incidence of injection pain during induction and better early postoperative sedation scores. The results suggest that remimazolam provides better hemodynamic stability without affecting the anesthetic effect, making it of high clinical value.