Gkiafi Z, Rozani S. New-onset diabetes mellitus after distal pancreatectomy: Incidence, predictors and clinical impact. World J Gastrointest Surg 2026; 18(6): 119845 [DOI: 10.4240/wjgs.119845]
Corresponding Author of This Article
Sofia Rozani, MD, PhD, Academic Fellow, Research Fellow, Department of Surgery II, Aretaieio University Hospital, National and Kapodistrian University of Athens, Vasileos Sofias Street 76, Athens 11528, Attikí, Greece. sofrozan@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
review-article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jun 27, 2026; 18(6): 119845 Published online Jun 27, 2026. doi: 10.4240/wjgs.119845
New-onset diabetes mellitus after distal pancreatectomy: Incidence, predictors and clinical impact
Zoi Gkiafi, Sofia Rozani
Zoi Gkiafi, Department of Surgery I, Laiko University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Attikí, Greece
Sofia Rozani, Department of Surgery II, Aretaieio University Hospital, National and Kapodistrian University of Athens, Athens 11528, Attikí, Greece
Author contributions: Gkiafi Z and Rozani S contributed to data extraction, validation, visualization and writing process at every part of this manuscript.
AI contribution statement: I use Grammarly for language polishing.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Sofia Rozani, MD, PhD, Academic Fellow, Research Fellow, Department of Surgery II, Aretaieio University Hospital, National and Kapodistrian University of Athens, Vasileos Sofias Street 76, Athens 11528, Attikí, Greece. sofrozan@gmail.com
Received: February 7, 2026 Revised: February 25, 2026 Accepted: March 18, 2026 Published online: June 27, 2026 Processing time: 134 Days and 16.5 Hours
Core Tip
Core Tip: New-onset diabetes mellitus is a frequent and clinically important consequence of distal pancreatectomy, driven by loss of β-cell mass and potential impairment of pancreatic remnant perfusion. Its incidence varies widely due to differences in surgical technique, underlying pathology, and patient metabolic status. Key determinants include preoperative glucose intolerance, pancreatic steatosis, patient age, and the volume and vascularization of the remnant gland. Recognizing these risk factors enables improved patient selection, early detection, and tailored follow-up strategies. This review highlights emerging evidence on modifiable operative considerations and underscores the need for targeted research to reduce new-onset diabetes mellitus risk.
