Bridging metabolism and tumorigenesis: Insights from the Wnt/β-Catenin/TCF7L2 pathway in association between type 2 diabetes and colorectal adenomas

doi:10.4240/wjgs.118213

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Jun 27, 2026; 18(6): 118213
Published online Jun 27, 2026. doi: 10.4240/wjgs.118213

Bridging metabolism and tumorigenesis: Insights from the Wnt/β-Catenin/TCF7L2 pathway in association between type 2 diabetes and colorectal adenomas

Kai-Lin Xue, Xiao-Hua Jia, Wan-Ting Qi, Jing-Wen Wang, Lei Liang

Kai-Lin Xue, Peking University Aerospace School of Clinical Medicine, Aerospace Center Hospital, Beijing 100049, China

Xiao-Hua Jia, Wan-Ting Qi, Jing-Wen Wang, Lei Liang, Department of Ultrasound, Aerospace Center Hospital, Beijing 100049, China

Co-first authors: Kai-Lin Xue and Xiao-Hua Jia.

Author contributions: Xue KL and Jia XH contributed to conceptualization, writing the original draft, and they contributed equally to this manuscript and are co-first authors; Xue KL, Jia XH, Qi WT, and Wang JW participated in searching for and organizing literature; Xue KL and Liang L contributed to reviewing and editing. All authors have read and approved the final manuscript.

Supported by National Natural Science Foundation of China, No. 62371010.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Lei Liang, MD, PhD, Professor, Department of Ultrasound, Aerospace Center Hospital, No. 15 Yuquan Street, Haidian District, Beijing 100049, China. lianglei_csk@126.com

Received: December 28, 2025
Revised: January 19, 2026
Accepted: January 26, 2026
Published online: June 27, 2026
Processing time: 170 Days and 16.2 Hours

Core Tip

Core Tip: Gui et al’s recent study identifies the Wnt/β-catenin/transcription factor 7 like 2 pathways as a potential molecular link between type 2 diabetes mellitus and colorectal adenomas. Despite the retrospective design and associated limitations, the study provides mechanistic insight beyond traditional hypotheses and highlights the need for further validation.