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World J Gastrointest Surg. Jun 27, 2026; 18(6): 117856
Published online Jun 27, 2026. doi: 10.4240/wjgs.117856
Published online Jun 27, 2026. doi: 10.4240/wjgs.117856
Synergistic effect of Codonopsis lanceolata and clip-line traction in endoscopic submucosal dissection for early esophageal cancer
Dai Shi, Department of Infectious Diseases, The Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi 214000, Jiangsu Province, China
Liang Zheng, Department of Gastroenterology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu Province, China.
Author contributions: Shi D contributed to data collection and paper writing; Shi D and Zheng L contributed to research design, data analysis; Zheng L was responsible for funding application, reviewing and editing, communication coordination, ethical review, copyright and licensing, and follow-up. All author approval the final manuscript.
Institutional review board statement: The research was reviewed and approved by the Wuxi Traditional Chinese Medicine Hospital (Approval No. 2025-585).
Clinical trial registration statement: This prospective randomized controlled trial was initiated in early 2023, during the transitional period of mandatory clinical trial registration policy at our hospital. The registration process for studies on traditional Chinese medicine as an adjunct therapy was not yet fully standardized, and administrative delays prevented us from completing prospective registration before patient enrollment.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: I have read the CONSORT 2010 statement and the manuscript has been written and revised based on the CONSORT 2010 statement.
Data sharing statement: No other data available.
Corresponding author: Liang Zheng, Chief Physician, Department of Gastroenterology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, No. 23 Nanhu Road, Jiandu District, Nanjing 210000, Jiangsu Province, China. sd479324634@163.com
Received: January 20, 2026
Revised: February 6, 2026
Accepted: March 10, 2026
Published online: June 27, 2026
Processing time: 151 Days and 15.9 Hours
Revised: February 6, 2026
Accepted: March 10, 2026
Published online: June 27, 2026
Processing time: 151 Days and 15.9 Hours
Core Tip
Core Tip: This randomized trial demonstrates that the perioperative administration of Taishan Codonopsis (Codonopsis lanceolata) combined with clipping wire traction-assisted endoscopic submucosal dissection offers significant clinical benefits for early esophageal cancer. This integrative strategy effectively attenuates systemic inflammation (reduced C-reactive protein), mitigates postoperative pain, expedites functional recovery, shortens hospital stay, enhances ulcer healing, and lowers complication rates, providing an effective and safe adjunct to modern endoscopic therapy.