Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. May 27, 2026; 18(5): 117809
Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.117809
Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.117809
Clinical comparison of laparoscopic vs open distal gastrectomy for advanced gastric cancer: Perioperative safety, recovery, and survival
Chun-Peng Pan, Chi-Hao Zhang, Shou-Lian Wang, Xiao-Chun Ni, Hai-Bo Wang, Ji-Wei Yu, Department of General Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
Co-first authors: Chun-Peng Pan and Chi-Hao Zhang.
Author contributions: Pan CP and Zhang CH are the co-first authors of this study and have made equal contributions, including study design, data collection and analysis, and manuscript preparation; Wang SL, Ni XC, and Wang HB designed the experiments and conducted clinical data collection, performed postoperative follow-up and recorded the data; Pan CP, Zhang CH, and Yu JW conducted the collation and statistical analysis, and wrote the original manuscript and revised the paper. All authors read and approved the final manuscript.
AI contribution statement: This paper was entirely completed by the author independently, and no AI tools were used throughout the entire creative process.
Institutional review board statement: This study was approved by the Ethics Committee of Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine (approval No. SH9H-2025-T525-1).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Corresponding author: Ji-Wei Yu, Department of General Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Huangpu District, Shanghai 200011, China. jenniferyu919@126.com
Received: January 9, 2026
Revised: January 27, 2026
Accepted: February 25, 2026
Published online: May 27, 2026
Processing time: 138 Days and 4.5 Hours
Revised: January 27, 2026
Accepted: February 25, 2026
Published online: May 27, 2026
Processing time: 138 Days and 4.5 Hours
Core Tip
Core Tip: This study demonstrates that totally laparoscopic distal gastrectomy for locally advanced gastric cancer provides short-term benefits over open distal gastrectomy, including reduced trauma, less blood loss, faster functional recovery, and lower pain scores, while achieving equivalent mid-term oncological outcomes. The 3-year overall survival and recurrence-free survival rates were comparable between the two techniques. Totally laparoscopic distal gastrectomy is a safe and effective minimally invasive alternative that does not compromise cancer control.