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World J Gastrointest Surg. May 27, 2026; 18(5): 116869
Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.116869
Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.116869
Dynamic monitoring of serum tumor markers in predicting recurrence after radical gastrectomy for gastric cancer
Wei-Hua Zhang, Chuan-Yue Zhong, Department of Oncology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou 215000, Jiangsu Province, China
Min Wu, Department of Gastroenterology, Suzhou Hospital Affiliated to Nanjing University Medical School, Suzhou 215000, Jiangsu Province, China
Author contributions: Zhang WH conceptualization, data curation, formal analysis, investigation, methodology, writing original draft, writing review and editing; Zhong CY data curation, investigation, patient follow-up, writing review and editing; Wu M conceptualization, methodology, supervision, writing review and editing, final approval of the manuscript.
Institutional review board statement: The study protocol was reviewed and approved by the Medical Ethics Committee of Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Jiangsu Province, China (Approval No. WJ20250SZ00125).
Informed consent statement: This study was retrospective in nature. The requirement for written informed consent was waived by the Medical Ethics Committee of Suzhou Hospital of Integrated Traditional Chinese and Western Medicine due to the use of anonymized clinical data.
Conflict-of-interest statement: The authors declare that they have no conflict of interest related to this study.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
Corresponding author: Chuan-Yue Zhong, Department of Oncology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, No. 39 Xiashatang, Wuzhong District, Suzhou 215000, Jiangsu Province, China. zop77@sohu.com
Received: December 26, 2025
Revised: January 29, 2026
Accepted: February 27, 2026
Published online: May 27, 2026
Processing time: 152 Days and 4.9 Hours
Revised: January 29, 2026
Accepted: February 27, 2026
Published online: May 27, 2026
Processing time: 152 Days and 4.9 Hours
Core Tip
Core Tip: Dynamic post-gastrectomy monitoring of serum markers (carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4, carbohydrate antigen 125) facilitates early identification of high-risk recurrence in gastric cancer. Progressive and recurrent elevation patterns markedly outperform single preoperative marker values (area under the curve up to 0.912), offering a streamlined, cost-effective strategy to refine follow-up and personalise surveillance.