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Du YL, Shi CJ, Gao FY, Xie SJ, Zhang MN, Zhang ZQ, Qiu W, Ming Y. Prognostic value of serum aldo-keto reductase family 1 member B10 in hepatocellular carcinoma. World J Gastrointest Surg 2026; 18(5): 116672 [DOI: 10.4240/wjgs.v18.i5.116672]
World J Gastrointest Surg. May 27, 2026; 18(5): 116672 Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.116672
Prognostic value of serum aldo-keto reductase family 1 member B10 in hepatocellular carcinoma
Yun-Ling Du, Chang-Jiang Shi, Fang-Yuan Gao, Shou-Jun Xie, Meng-Na Zhang, Zhu-Qing Zhang, Wei Qiu, Ying Ming
Yun-Ling Du, Shou-Jun Xie, Meng-Na Zhang, Zhu-Qing Zhang, Wei Qiu, Ying Ming, Department of Laboratory Medicine, The Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China
Chang-Jiang Shi, Department of Joint Surgery, The Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China
Fang-Yuan Gao, Department of Integrated Traditional Chinese and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100000, China
Author contributions: Du YL designed the research and wrote the first manuscript; Du YL, Shi CJ, Gao FY, Xie SJ, Zhang MN, Zhang ZQ and Qiu W contributed to conceiving the research and analyzing data; Du YL and Ming Y conducted the analysis and provided guidance for the research. All authors reviewed and approved the final manuscript.
Supported by the Science and Technology Program of Chengde, No. 202109A064.
Institutional review board statement: The study was approved by the Institutional Review Board of the Affiliated Hospital of Chengde Medical University (Approval No. CYFYLL2021104).
Informed consent statement: Because this study used anonymized data, informed consent was not required.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Ying Ming, MM, Department of Laboratory Medicine, The Affiliated Hospital of Chengde Medical University, No. 36 Nanyingzi Street, Shuangqiao District, Chengde 067000, Hebei Province, China. 18503145756@163.com
Received: January 13, 2026 Revised: February 4, 2026 Accepted: March 10, 2026 Published online: May 27, 2026 Processing time: 134 Days and 4.1 Hours
Core Tip
Core Tip: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Despite recent improvements in diagnostic approaches and surgical techniques, the five-year survival rate for patients with advanced HCC remains low, largely due to the absence of early clinical symptoms and the lack of reliable diagnostic and prognostic biomarkers. Over the past decade, aldo-keto reductase family 1 member 10 has emerged as a potential biomarker for both the diagnosis and prognosis of HCC. This study aimed to investigate the correlation between serum aldo-keto reductase family 1 member 10 levels and prognosis in patients with HCC, evaluate its clinical value as a prognostic indicator, and provide a theoretical basis and research direction for individualized treatment strategies.
