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World Journal of Gastrointestinal Surgery
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1948-9366
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. May 27, 2026; 18(5): 114634
Published online May 27, 2026. doi: 10.4240/wjgs.v18.i5.114634
Systemic immune-inflammation index and serum lactoferrin: A novel tool for individualized prognostic assessment in elderly colon cancer
Shu-Qi Ren, Zhuo-Ling Huang, Zu-Xun Qiu, Chuang Cai
Shu-Qi Ren, Zhuo-Ling Huang, Zu-Xun Qiu, Department of Laboratory Medicine, Zhongshan City Hospital of Integration of TCM & Western Medicine, Zhongshan 528467, Guangdong Province, China
Chuang Cai, Cancer Research Institute of Zhongshan City, Zhongshan City People's Hospital, Zhongshan 528445, Guangdong Province, China
Author contributions: Ren SQ, Huang ZL, Qiu ZX and Cai C made substantial contributions to this manuscript; Ren SQ conceived the review and drafted the initial manuscript; Huang ZL and Qiu ZX were responsible for literature collation; Ren SQ and Cai C edited and finalized the manuscript for submission. All authors reviewed and approved the submitted manuscript.
Conflict-of-interest statement: All authors disclose no financial relationships relevant to this publication.
Corresponding author: Chuang Cai, PhD, Assistant Professor, Cancer Research Institute of Zhongshan City, Zhongshan City People's Hospital, No. 2 Sunwen East Road, Zhongshan 528445, Guangdong Province, China. caich6@foxmail.com
Received: September 24, 2025
Revised: December 15, 2025
Accepted: December 26, 2025
Published online: May 27, 2026
Processing time: 245 Days and 7.2 Hours
Core Tip

Core Tip: This prospective study identifies elevated preoperative systemic immune-inflammation index combined with low serum lactoferrin as independent prognostic biomarkers in elderly colon cancer patients. This cost-effective and easily measurable combination reflects both systemic inflammatory burden and immune-nutritional status, enhancing traditional tumor node metastasis staging. It holds substantial potential for individualized postoperative risk stratification in routine clinical practice.
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