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World J Gastrointest Surg. Feb 27, 2026; 18(2): 114743
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.114743
Published online Feb 27, 2026. doi: 10.4240/wjgs.v18.i2.114743
Psoas muscle variables and adjuvant chemotherapy-related and survival outcomes following pancreaticoduodenectomy for periampullary malignancy
Shahin Hajibandeh, Hamish Mckittrick, Damien Durkin, Tejinderjit S Athwal, Department of Hepatobiliary and Pancreatic Surgery, Royal Stoke University Hospital, Stoke-on-Trent ST4 6QG, United Kingdom
Shahin Hajibandeh, Hepatobiliary and Pancreatic Surgery and Liver Transplant Unit, Queen Elizabeth Hospital Birmingham, Birmingham B15 2GW, United Kingdom
Shahab Hajibandeh, Department of Hepatobiliary and Pancreatic Surgery, Manchester Royal Infirmary Hospital, Manchester M13 9WL, United Kingdom
Usman Imrani, Abin Varghese, Ravivarma Balasubramaniam, Department of Radiology, Royal Stoke University Hospital, Stoke-on-Trent ST4 6QG, United Kingdom
Author contributions: Hajibandeh S (the first author) did conception and design; Mckittrick H, Imrani U, and Varghese A performed literature search and data extraction; Hajibandeh S (the first author) and Hajibandeh S (the second author) contributed to analysis and writing the manuscript. All authors approved the final version to publish.
Institutional review board statement: This study had a retrospective design involving non-identifiable data from hospital databases, approval by Ethics Committees was not needed.
Informed consent statement: Considering that this study had a retrospective design involving non-identifiable data from hospital databases, patient consent was not needed.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data used in this study will be available on request.
Corresponding author: Shahin Hajibandeh, FRC, Senior Researcher, Department of Hepatobi
Received: September 28, 2025
Revised: November 6, 2025
Accepted: December 16, 2025
Published online: February 27, 2026
Processing time: 152 Days and 17.7 Hours
Revised: November 6, 2025
Accepted: December 16, 2025
Published online: February 27, 2026
Processing time: 152 Days and 17.7 Hours
Core Tip
Core Tip: Preoperative Hounsfield unit average calculation, determined from psoas muscle area and density, may predict time to adjuvant chemotherapy (AC), AC-related toxicity and completion of AC following pancreaticoduodenectomy for periampullary cancers. However, its ability to predict survival should be evaluated by future research. This study aims to evaluate ability of Hounsfield unit average calculation and psoas muscle index in predicting AC-related and survival outcomes following pancreaticoduodenectomy for periampullary malignancy.