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World J Gastrointest Surg. Oct 27, 2026; 18(10): 122160
Published online Oct 27, 2026. doi: 10.4240/wjgs.122160
Published online Oct 27, 2026. doi: 10.4240/wjgs.122160
Recurrence risk prediction of small-molecule drugs plus chemo in postoperative gastric cancer: Retrospective analysis via molecular markers
Yong Yang, Xing-Yong Yang, Xue Li, Li-Jun Cui, Department of Blood Transfusion, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Han-Dan Liu, Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Co-first authors: Yong Yang and Han-Dan Liu.
Author contributions: Yang Y and Liu HD contributed equally to this work as co-first authors and they participated in research design, data collection, statistical analysis, and manuscript drafting; Cui LJ is the corresponding author and responsible for project supervision, critical revision of the manuscript, and final approval; Yang XY and Li X assisted in data collation, literature review and manuscript revision; and all the authors have read and approved the final manuscript.
AI contribution statement: The authors declare that no AI tools were used in the development or writing of this manuscript and take full responsibility for its integrity, accuracy, and originality.
Institutional review board statement: This study has been reviewed and approved by the Medical Ethics Committee of Affiliated Hospital of North Sichuan Medical College (Approval No. 2025ER715-1).
Informed consent statement: All the individuals who participated in this study provided their written informed consent prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Corresponding author: Li-Jun Cui, Chief Physician, Department of Blood Transfusion, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan South Road, Shunqing District, Nanchong 637000, Sichuan Province, China. liuhandan1013@163.com
Received: April 30, 2026
Revised: May 25, 2026
Accepted: June 12, 2026
Published online: October 27, 2026
Processing time: 164 Days and 2.6 Hours
Revised: May 25, 2026
Accepted: June 12, 2026
Published online: October 27, 2026
Processing time: 164 Days and 2.6 Hours
Core Tip
Core Tip: This study retrospectively analyzed 136 patients with postoperative gastric cancer receiving small-molecule drugs and chemotherapy. Programmed death-ligand 1 and tumor mutation burden are independent risk factors for recurrence, and their combined detection has a high predictive value.