Diabetes mellitus, glycemic control, and risk of postoperative infectious complications in gastric and colorectal cancer surgery

doi:10.4240/wjgs.v18.i10.120959

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Surg. Oct 27, 2026; 18(10): 120959
Published online Oct 27, 2026. doi: 10.4240/wjgs.v18.i10.120959

Diabetes mellitus, glycemic control, and risk of postoperative infectious complications in gastric and colorectal cancer surgery

Andrea Cavallaro

Andrea Cavallaro, Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania 95123, Sicily, Italy

Author contributions: Cavallaro A designed the study, performed the literature review, and wrote the manuscript; and the author approved the final version of the manuscript.

Conflict-of-interest statement: The author declares no conflicts of interest relevant to this manuscript.

Corresponding author: Andrea Cavallaro, MD, Research Assistant Professor, Department of General Surgery and Medical Surgical Specialties, University of Catania, Via S. Sofia 78, Catania 95123, Sicily, Italy. andreacavallaro@tiscali.it

Received: March 12, 2026
Revised: April 7, 2026
Accepted: April 21, 2026
Published online: October 27, 2026
Processing time: 221 Days and 8.2 Hours

Core Tip

Core Tip: Diabetes mellitus and perioperative hyperglycemia significantly increase the risk of infectious complications and anastomotic failure in gastrointestinal surgery. The recent findings by Peng et al underscore that preoperative glycated hemoglobin levels and albumin status are essential biomarkers for risk stratification. Beyond systemic infections, metabolic dysfunction directly impairs collagen synthesis, linking hyperglycemia to surgical site infections and micro-leaks. Surgeons must adopt a multidisciplinary approach focused on glycemic control and nutritional optimization to mitigate these risks in the growing population of diabetic oncologic patients.