Lin XJ, Xu JZ, Hu Q, Chen J. Effects of enhanced recovery after surgery on postoperative intestinal function and intestinal flora during laparoscopic gastric cancer surgery. World J Gastrointest Surg 2025; 17(9): 106286 [DOI: 10.4240/wjgs.v17.i9.106286]
Corresponding Author of This Article
Jie Chen, Department of Mammography, Vascular Surgery, Hepatobiliary and Pancreatic Surgery, Zhejiang Tongde Hospital, No. 234 Gucui Road, Xihu District, Hangzhou 310000, Zhejiang Province, China. dmhz15700058313@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Sep 27, 2025; 17(9): 106286 Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.106286
Effects of enhanced recovery after surgery on postoperative intestinal function and intestinal flora during laparoscopic gastric cancer surgery
Xiao-Jie Lin, Jia-Ze Xu, Qiang Hu, Jie Chen
Xiao-Jie Lin, Jie Chen, Department of Mammography, Vascular Surgery, Hepatobiliary and Pancreatic Surgery, Zhejiang Tongde Hospital, Hangzhou 310000, Zhejiang Province, China
Jia-Ze Xu, Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Tongde Hospital, Hangzhou 310000, Zhejiang Province, China
Qiang Hu, Department of Gastroenterology and Pancreatic Surgery, Zhejiang Tongde Hospital, Hangzhou 310000, Zhejiang Province, China
Author contributions: Lin XJ carried out conceptualization, statistical analysis, manuscript writing and revision; Xu JZ performed patient recruitment, clinical data management and manuscript review; Lin XJ and Xu JZ performed data collection; Hu Q performed the study design, microbiota analyses, interpretation of results, and critical revision of the manuscript; Chen J conducted research guidance, methodological design, funding acquisition, final manuscript approval and correspondence; and all authors contributed to the article and approved the submitted version.
Supported by the Zhejiang Provincial Science and Technology Project for Traditional Chinese Medicine, No. 2024ZL345.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Zhejiang Provincial Tongde Hospital, approval No. ZJTD-IRB-2022-074.
Informed consent statement: Informed consent was waived due to the retrospective nature of the study and the use of anonymized data, as approved by the institutional ethics committee.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Chen, Department of Mammography, Vascular Surgery, Hepatobiliary and Pancreatic Surgery, Zhejiang Tongde Hospital, No. 234 Gucui Road, Xihu District, Hangzhou 310000, Zhejiang Province, China. dmhz15700058313@163.com
Received: April 8, 2025 Revised: June 3, 2025 Accepted: August 4, 2025 Published online: September 27, 2025 Processing time: 169 Days and 0.2 Hours
Core Tip
Core Tip: Enhanced recovery after surgery significantly accelerates gastrointestinal recovery, as demonstrated by earlier return of bowel sounds, flatus, and defecation compared to traditional care. It also preserves microbiota diversity, maintaining higher diversity indices and a healthier balance of beneficial bacteria, though neither group fully recovered preoperative levels by one month. Importantly, this enhanced recovery is achieved without an increase in postoperative complications, such as surgical site infections or antibiotic-associated diarrhea. Subgroup analyses reveal that younger patients benefit the most, showing faster recovery timelines. These findings underscore the clinical advantages of enhanced recovery after surgery protocols in laparoscopic gastric cancer surgery, providing strong support for their adoption.
