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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2025; 17(9): 105983
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.105983
Published online Sep 27, 2025. doi: 10.4240/wjgs.v17.i9.105983
Application effect of linaclotide capsules combined with compound polyethylene glycol in colonoscopy bowel preparation
Li-Wei Xue, Yi-Qian Zhang, Wei-Lai Yu, Department of Gastroenterology, Rui'an People's Hospital/The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China
Zai-Bo Wen, Department of Gastroenterology, The People's Hospital of Cangnan, Wenzhou 325800, Zhejiang Province, China
Author contributions: Xue LW initiated the project; Zhang YQ and Yu WL designed the experiment and conducted clinical data collection, performed postoperative follow-up and recorded data; Xue LW and Wen ZB conducted a number of collation and statistical analysis, and wrote the original manuscript; all authors have read and approved the final manuscript.
Supported by the Science and Technology Program of Rui’an, No. MS2023030.
Institutional review board statement: This study was approved by the Ethics Committee of Rui'an People's Hospital/The Third Affiliated Hospital of Wenzhou Medical University (No. YJ2024044).
Informed consent statement: The Ethics Committee agrees to waive informed consent.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zai-Bo Wen, Department of Gastroenterology, The People's Hospital of Cangnan, No. 2288 Yuchang Road, Lingxi Town, Cangnan County, Wenzhou 325800, Zhe
Received: May 9, 2025
Revised: June 6, 2025
Accepted: July 22, 2025
Published online: September 27, 2025
Processing time: 138 Days and 1.2 Hours
Revised: June 6, 2025
Accepted: July 22, 2025
Published online: September 27, 2025
Processing time: 138 Days and 1.2 Hours
Core Tip
Core Tip: Compound polyethylene glycol electrolyte powder (SF-PEG) is a commonly used intestinal cleaner, but some elderly patients have poor tolerance to it. Linalotide can improve intestinal preparation by increasing small intestinal fluid secretion and intestinal peristalsis. In this study, group C (bowel preparation with 2 L of SF-PEG combined with linaclotide) had significantly lower withdrawal time and incidence of adverse reactions compared to group B (bowel preparation with 3 L of SF-PEG), indicating that linaclotide capsules have a tendency to improve intestinal preparation quality, reduce SF-PEG dosage, help reduce patient discomfort, and make colonoscopy easier for patients.