Wu SW, Rong Y, Chen GJ, Cao XS, Xie ZY, Wu B, Huang HC, Wang ZW, Wu XX. Anal adenocarcinoma with perianal Paget's disease: A case report. World J Gastrointest Surg 2025; 17(8): 108963 [PMID: 40949398 DOI: 10.4240/wjgs.v17.i8.108963]
Corresponding Author of This Article
Xiao-Xiang Wu, Chief Physician, Professor, Department of General Surgery, General Hospital of Southern Theater Command, No. 111 Liuhua Road, Yuexiu District, Guangzhou 510000, Guangdong Province, China. 786486617@qq.com
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Aug 27, 2025; 17(8): 108963 Published online Aug 27, 2025. doi: 10.4240/wjgs.v17.i8.108963
Anal adenocarcinoma with perianal Paget's disease: A case report
Sheng-Wei Wu, Yao Rong, Gui-Jin Chen, Xu-Song Cao, Zheng-Yong Xie, Bei Wu, Hao-Chun Huang, Zhi-Wei Wang, Xiao-Xiang Wu
Sheng-Wei Wu, Yao Rong, Gui-Jin Chen, Xu-Song Cao, Zheng-Yong Xie, Bei Wu, Hao-Chun Huang, Zhi-Wei Wang, Xiao-Xiang Wu, Department of General Surgery, General Hospital of Southern Theater Command, Guangzhou 510000, Guangdong Province, China
Co-first authors: Sheng-Wei Wu and Yao Rong.
Co-corresponding authors: Zhi-Wei Wang and Xiao-Xiang Wu.
Author contributions: Wu SW and Rong Y contribute equally to this study as co-first authors; Wang ZW and Wu XX contribute equally to this study as co-corresponding authors; Wu SW and Rong Y contributed to manuscript writing and editing; Chen GJ, Cao XS and Xie ZY contribute to the collection of data; Wu B and Huang HC contributed to the production of figures and table; Wang ZW and Wu XX contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Supported by Guangdong Provincial Medical Research Fund General Program, No. B2025209.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Xiang Wu, Chief Physician, Professor, Department of General Surgery, General Hospital of Southern Theater Command, No. 111 Liuhua Road, Yuexiu District, Guangzhou 510000, Guangdong Province, China. 786486617@qq.com
Received: April 27, 2025 Revised: June 5, 2025 Accepted: July 7, 2025 Published online: August 27, 2025 Processing time: 121 Days and 1.4 Hours
Core Tip
Core Tip: Perianal Paget's disease (PPD), particularly secondary PPD associated with anal adenocarcinoma, is frequently misdiagnosed due to nonspecific symptoms resembling hemorrhoids or eczema. This case highlights a 72-year-old female with a 2-year misdiagnosis history, ultimately confirmed via colonoscopy, biopsy, and immunohistochemistry [IHC; CK7(+)/CK20(+)/CDX2(+)/CEA(+)]. Successful treatment with 3D laparoscopic abdominoperineal resection and extended perianal excision underscores the importance of early IHC testing in refractory perianal symptoms. Key takeaways: (1) Secondary PPD requires high clinical suspicion in elderly patients with chronic perianal lesions; (2) Multimodal diagnostics (endoscopy, biopsy, IHC) are critical to differentiate primary/secondary PPD; and (3) Radical resection ensures oncologic safety, while structured follow-up prevents recurrence.
