This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jul 27, 2025; 17(7): 107804 Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.107804
Preoperative computed tomography-based risk stratification model validation for postoperative pancreatic ductal adenocarcinoma recurrence
Xiao-Hui Liu, Jing-Hong Xie, Xi-Song Zhu, Li-Heng Liu
Xiao-Hui Liu, Xi-Song Zhu, Department of Radiology, Wenzhou Medical University Affiliated Quzhou Hospital (Quzhou People's Hospital), Quzhou 324000, Zhejiang Province, China
Xiao-Hui Liu, Li-Heng Liu, Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200000, China
Jing-Hong Xie, Department of Radiology, Qingdao Eighth People's Hospital, Qingdao 266000, Shandong Province, China
Author contributions: Liu LH designed the study, participated in data analysis, and drafted and critically revised the manuscript for important intellectual content; Liu XH and Xie JH collected the patients’ clinical data; Zhu XS served as a scientific advisor and contributed to the interpretation of results; All authors reviewed and approved the final version of the manuscript and agree to be accountable for all aspects of the work.
Institutional review board statement: The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
Informed consent statement: Zhongshan Hospital Institutional Review Board approved this retrospective study and waived the requirement for informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated or analyzed during the study are available from the corresponding author on reasonable request at liu.liheng@zs-hospital.sh.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: March 30, 2025 Revised: April 16, 2025 Accepted: May 20, 2025 Published online: July 27, 2025 Processing time: 116 Days and 21.4 Hours
Core Tip
Core Tip: This multinational study externally validated a preoperative computed tomography-based risk model, originally developed in South Korea, for predicting recurrence-free survival (RFS) in patients with pancreatic ductal adenocarcinoma (PDAC), after surgery. Analyzing 283 patients from a distinct population, the model-incorporating tumor size, portal venous phase density, necrosis, peripancreatic infiltration, and metastatic lymph nodes-stratified patients into prognostic groups. The good prognosis group exhibited significantly longer RFS despite a 76% overall recurrence rate. The findings confirm its cross-population applicability, supporting its use as a preoperative tool to identify patients at high risk of PDAC and guide clinical decision-making.
